The much-publicised increased resistance of pathogenic bacteria to conventional antibiotics has focused researcheffort on the characterization of new antimicrobial drugs. In this context, antimicrobial peptides (AMPs)extracted from animals are considered a promising alternative to conventional antibiotics. In recent years,freshwater crayfish species have emerged as an important source of bioactive compounds. In fact, these invertebrates rely on an innate immune system based on cellular responses and on the production of importanteffectors in the haemolymph, such as AMPs, which are produced and stored in granules in haemocytes andreleased after stimulation. These effectors are active against both Gram-positive and Gram-negative bacteria. Inthis review, we summarise the recent progress on AMPs isolated from the several species of freshwater crayfishand their prospects for future pharmaceutical applications to combat infectious agents.
|Numero di pagine||10|
|Rivista||Developmental and Comparative Immunology|
|Stato di pubblicazione||Published - 2022|
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