The potential of antimicrobial peptides isolated from freshwater crayfishspecies in new drug development: A review

Risultato della ricerca: Articlepeer review

Abstract

The much-publicised increased resistance of pathogenic bacteria to conventional antibiotics has focused researcheffort on the characterization of new antimicrobial drugs. In this context, antimicrobial peptides (AMPs)extracted from animals are considered a promising alternative to conventional antibiotics. In recent years,freshwater crayfish species have emerged as an important source of bioactive compounds. In fact, these invertebrates rely on an innate immune system based on cellular responses and on the production of importanteffectors in the haemolymph, such as AMPs, which are produced and stored in granules in haemocytes andreleased after stimulation. These effectors are active against both Gram-positive and Gram-negative bacteria. Inthis review, we summarise the recent progress on AMPs isolated from the several species of freshwater crayfishand their prospects for future pharmaceutical applications to combat infectious agents.
Lingua originaleEnglish
pagine (da-a)1-10
Numero di pagine10
RivistaDevelopmental and Comparative Immunology
Volume126
Stato di pubblicazionePublished - 2022

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1309???

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