The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity

Marcello Ciaccio, Mattia Emanuela Ligotti, Anna Aiello, Giuseppina Candore, Sonya Vasto, Calogero Caruso, Caterina Maria Gambino, Giulia Accardi, Marcello Ciaccio, Sergio Davinelli, Damiano Galimberti, Paolo Colomba, Rosalia Caldarella, Angelo Zinellu, Immaculata De Vivo, Giuseppe Cammarata, Ciriaco Carru, Calogero Caruso

Risultato della ricerca: Articlepeer review

Abstract

This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.
Lingua originaleEnglish
pagine (da-a)476-484
Numero di pagine9
RivistaRejuvenation Research
Volume23
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2717???

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