12 Citazioni (Scopus)

Abstract

Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake and/or export of lipids through the villus enterocytes. Once secreted in the lymph stream, triglyceride-rich lipoproteins (TRLs) are metabolized by Lipoprotein lipase (LPL), which catalyzes the hydrolysis of triacylglycerols of very low density lipoproteins (VLDLs) and chylomicrons, thereby delivering free fatty acids to various tissues. Genetic mutations in the genes codifying for these proteins are responsible of different inherited disorders affecting chylomicron metabolism. This review focuses on the molecular pathways that modulate the uptake and the transport of lipoproteins of intestinal origin and it will highlight recent findings on TRLs assembly.
Lingua originaleEnglish
pagine (da-a)61-
Numero di pagine10
RivistaFrontiers in Physiology
Volume6
Stato di pubblicazionePublished - 2015

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Chylomicrons
Lipoproteins
Triglycerides
VLDL Lipoproteins
Lipoprotein Lipase
Enterocytes
Dietary Fats
Lymph
Nonesterified Fatty Acids
Vitamins
Endoplasmic Reticulum
Phospholipids
Hydrolysis
Fats
Lipids
Mutation
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cita questo

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title = "The pathophysiology of intestinal lipoprotein production",
abstract = "Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake and/or export of lipids through the villus enterocytes. Once secreted in the lymph stream, triglyceride-rich lipoproteins (TRLs) are metabolized by Lipoprotein lipase (LPL), which catalyzes the hydrolysis of triacylglycerols of very low density lipoproteins (VLDLs) and chylomicrons, thereby delivering free fatty acids to various tissues. Genetic mutations in the genes codifying for these proteins are responsible of different inherited disorders affecting chylomicron metabolism. This review focuses on the molecular pathways that modulate the uptake and the transport of lipoproteins of intestinal origin and it will highlight recent findings on TRLs assembly.",
keywords = "Assembly, Chylomicron, Inherited disorders, Physiology, Physiology (medical), Secretion, Triglyceride-rich lipoproteins",
author = "Maurizio Averna and Antonina Giammanco and Cefalu', {Angelo Baldassare} and Davide Noto",
year = "2015",
language = "English",
volume = "6",
pages = "61--",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

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TY - JOUR

T1 - The pathophysiology of intestinal lipoprotein production

AU - Averna, Maurizio

AU - Giammanco, Antonina

AU - Cefalu', Angelo Baldassare

AU - Noto, Davide

PY - 2015

Y1 - 2015

N2 - Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake and/or export of lipids through the villus enterocytes. Once secreted in the lymph stream, triglyceride-rich lipoproteins (TRLs) are metabolized by Lipoprotein lipase (LPL), which catalyzes the hydrolysis of triacylglycerols of very low density lipoproteins (VLDLs) and chylomicrons, thereby delivering free fatty acids to various tissues. Genetic mutations in the genes codifying for these proteins are responsible of different inherited disorders affecting chylomicron metabolism. This review focuses on the molecular pathways that modulate the uptake and the transport of lipoproteins of intestinal origin and it will highlight recent findings on TRLs assembly.

AB - Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake and/or export of lipids through the villus enterocytes. Once secreted in the lymph stream, triglyceride-rich lipoproteins (TRLs) are metabolized by Lipoprotein lipase (LPL), which catalyzes the hydrolysis of triacylglycerols of very low density lipoproteins (VLDLs) and chylomicrons, thereby delivering free fatty acids to various tissues. Genetic mutations in the genes codifying for these proteins are responsible of different inherited disorders affecting chylomicron metabolism. This review focuses on the molecular pathways that modulate the uptake and the transport of lipoproteins of intestinal origin and it will highlight recent findings on TRLs assembly.

KW - Assembly

KW - Chylomicron

KW - Inherited disorders

KW - Physiology

KW - Physiology (medical)

KW - Secretion

KW - Triglyceride-rich lipoproteins

UR - http://hdl.handle.net/10447/127393

UR - http://journal.frontiersin.org/article/10.3389/fphys.2015.00061/full

M3 - Article

VL - 6

SP - 61-

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

ER -