The nucleosome remodeling factor ISWI functionally interacts with an evolutionarily conserved network of cellular factors

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Abstract

ISWI is an evolutionarily conserved ATP-dependent chromatin remodeling factor playing central roles in DNA replication, RNA transcription, and chromosome organization. The variety of biological functions dependent on ISWI suggests that its activity could be highly regulated. Our group has previously isolated and characterized new cellular activities that positively regulate ISWI in Drosophila melanogaster. To identify factors that antagonize ISWI activity we developed a novel in vivo eye-based assay to screen for genetic suppressors of ISWI. Our screen revealed that ISWI interacts with an evolutionarily conserved network of cellular and nuclear factors that escaped previous genetic and biochemical analyses.
Lingua originaleEnglish
pagine (da-a)129-140
Numero di pagine12
RivistaGenetics
Volume185 (1)
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Genetics

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