The Nucleosome-Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation.

Davide Corona, Giosalba Burgio, Elena Kotova, Alexei V. Tulin, Anna Sala, Dario Di Gesu'

Risultato della ricerca: Article

43 Citazioni (Scopus)

Abstract

ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers.
Lingua originaleEnglish
pagine (da-a)e252-e252
Numero di pagine0
RivistaPLoS Biology
Volume6
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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    Corona, D., Burgio, G., Kotova, E., Tulin, A. V., Sala, A., & Di Gesu', D. (2008). The Nucleosome-Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation. PLoS Biology, 6, e252-e252.