The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis

Mariangela Sciandra, Alessandra Romano, Emanuele D'Amico, Giuseppe Alberto Maria Palumbo, Aurora Zanghì, Emanuele D'Amico, Emanuele D'Amico, Francesco Patti

Risultato della ricerca: Articlepeer review

10 Citazioni (Scopus)

Abstract

Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral bloodhas been investigated in relation to several autoimmune diseases. Limited studies have addressedthe significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS).Methods: This is a retrospective study in relapsing–remitting MS patients (RRMS) admitted to thetertiary MS center of Catania, Italy during the period of 1 January to 31 December 2018. The aim ofthe present study was to investigate the significance of the NLR in reflecting the disease activity in acohort of early diagnosed RRMS patients. Results: Among a total sample of 132 patients diagnosedwith RRMS, 84 were enrolled in the present study. In the association analysis, a relation betweenthe NLR value and disease activity at onset was found (V-Cramer 0.271, p = 0.013). In the logisticregression model, the variable NLR (p = 0.03 ExpB 3.5, CI 95% 1.089–11.4) was related to diseaseactivity at onset. Conclusion: An elevated NLR is associated with disease activity at onset in RRMSpatients. More large-scale studies with a longer follow-up are needed.
Lingua originaleEnglish
pagine (da-a)1-8
Numero di pagine8
RivistaCells
Volume8
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1400.1407???
  • ???subjectarea.asjc.1400.1408???
  • ???subjectarea.asjc.1800.1803???
  • ???subjectarea.asjc.2200.2209???
  • ???subjectarea.asjc.2200.2213???
  • ???subjectarea.asjc.2300.2311???
  • ???subjectarea.asjc.2700.2700???

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