5 Citazioni (Scopus)

Abstract

Alzheimer disease (AD) is the most common form of dementia with complex etiology and multifactorial origin. Although several neurochemical deficits have been described in AD patients, explanation of the nature of the cognitive disturbance is focused on the "cholinergic hypothesis." The neuronal nicotinic acetylcholine receptor (neuronal nAChR) belongs to the superfamily of ionic channel activated by ligand. This paper presents a population-based population association study, testing the hypothesis that variants of the nAChR gene confer genetic susceptibility to AD. The authors analyzed two cohorts constituted by 60 controls and 80 AD patients in which significant increase of 594T polymorphism in patients affected by AD versus controls was found. However, further studies are necessary to confirm this polymorphism trend and to establish the polymorphism functionality and its correlation with behavioral and cognitive deficit.
Lingua originaleEnglish
pagine (da-a)107-110
Numero di pagine4
RivistaRejuvenation Research
Volume9
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Ageing

Cita questo

The nACHR4 594C/T polymorphism in Alzheimer disease. /.

In: Rejuvenation Research, Vol. 9, 2006, pag. 107-110.

Risultato della ricerca: Article

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title = "The nACHR4 594C/T polymorphism in Alzheimer disease",
abstract = "Alzheimer disease (AD) is the most common form of dementia with complex etiology and multifactorial origin. Although several neurochemical deficits have been described in AD patients, explanation of the nature of the cognitive disturbance is focused on the {"}cholinergic hypothesis.{"} The neuronal nicotinic acetylcholine receptor (neuronal nAChR) belongs to the superfamily of ionic channel activated by ligand. This paper presents a population-based population association study, testing the hypothesis that variants of the nAChR gene confer genetic susceptibility to AD. The authors analyzed two cohorts constituted by 60 controls and 80 AD patients in which significant increase of 594T polymorphism in patients affected by AD versus controls was found. However, further studies are necessary to confirm this polymorphism trend and to establish the polymorphism functionality and its correlation with behavioral and cognitive deficit.",
author = "Giuseppina Candore and Domenico Lio and Vito Ditta and Alessandra Aquino and Balistreri, {Carmela Rita} and Sonya Vasto and Grimaldi, {Maria Paola} and Matteo Bulati",
year = "2006",
language = "English",
volume = "9",
pages = "107--110",
journal = "Rejuvenation Research",
issn = "1549-1684",
publisher = "Mary Ann Liebert Inc.",

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TY - JOUR

T1 - The nACHR4 594C/T polymorphism in Alzheimer disease

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Ditta, Vito

AU - Aquino, Alessandra

AU - Balistreri, Carmela Rita

AU - Vasto, Sonya

AU - Grimaldi, Maria Paola

AU - Bulati, Matteo

PY - 2006

Y1 - 2006

N2 - Alzheimer disease (AD) is the most common form of dementia with complex etiology and multifactorial origin. Although several neurochemical deficits have been described in AD patients, explanation of the nature of the cognitive disturbance is focused on the "cholinergic hypothesis." The neuronal nicotinic acetylcholine receptor (neuronal nAChR) belongs to the superfamily of ionic channel activated by ligand. This paper presents a population-based population association study, testing the hypothesis that variants of the nAChR gene confer genetic susceptibility to AD. The authors analyzed two cohorts constituted by 60 controls and 80 AD patients in which significant increase of 594T polymorphism in patients affected by AD versus controls was found. However, further studies are necessary to confirm this polymorphism trend and to establish the polymorphism functionality and its correlation with behavioral and cognitive deficit.

AB - Alzheimer disease (AD) is the most common form of dementia with complex etiology and multifactorial origin. Although several neurochemical deficits have been described in AD patients, explanation of the nature of the cognitive disturbance is focused on the "cholinergic hypothesis." The neuronal nicotinic acetylcholine receptor (neuronal nAChR) belongs to the superfamily of ionic channel activated by ligand. This paper presents a population-based population association study, testing the hypothesis that variants of the nAChR gene confer genetic susceptibility to AD. The authors analyzed two cohorts constituted by 60 controls and 80 AD patients in which significant increase of 594T polymorphism in patients affected by AD versus controls was found. However, further studies are necessary to confirm this polymorphism trend and to establish the polymorphism functionality and its correlation with behavioral and cognitive deficit.

UR - http://hdl.handle.net/10447/23957

M3 - Article

VL - 9

SP - 107

EP - 110

JO - Rejuvenation Research

JF - Rejuvenation Research

SN - 1549-1684

ER -