The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation

Gaetano Felice Caldara, Giacomo Azzali, Maria Luisa Arcari, Gaetano Felice Caldara

Risultato della ricerca: Articlepeer review

22 Citazioni (Scopus)


The mode of lymphocyte transendothelial migration in the postcapillary high endothelial venules (HEVs) of Peyer's patches during normal homing and acute inflammation in the guinea pig was studied. It is common opinion that the lymphocyte transendothelial passage from the blood stream into the extravasal lymphoid tissue calls for a multistep process of endothelial and lymphocyte molecules favoring tethering, rolling, activation, arrest and its firm adhesion to the endothelial luminal surface. Ultrastructural serial pictures and the three-dimensional reconstruction of HEVs with lymphocytes during different moments of their transmigration through the endothelial wall enabled us to demonstrate in vivo the morphological modality of their extravasation in lymphoid tissue. The latter is accomplished by means of an intraendothelial canalicular formation (6.8-7.2 microm long and 2.1-2.2 microm in diameter), whose creation depends on the particular behavior of adjacent endothelial cells, without compromising the interendothelial contacts. This new canalicular pathway of lymphocyte extravasation, particularly selective for the B cell, does not permit confirmation of the dogmas of the transcellular and paracellular (open interendothelial junctions) modes that have prevailed in recent decades. The lack of knowledge regarding the molecular bases that would induce constitution of this intraendothelial canalicular formation is a critical point for stimulating future interdisciplinary research aimed at developing strategies for modulating normal lymphocyte homing and in inflammation.
Lingua originaleEnglish
pagine (da-a)227-237
Numero di pagine11
RivistaMicrovascular Research
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.2700.2705???
  • ???subjectarea.asjc.1300.1307???


Entra nei temi di ricerca di 'The “mode” of lymphocyte extravasation through HEV of Peyer's patches and its role in normal homing and inflammation'. Insieme formano una fingerprint unica.

Cita questo