Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 372-377 |
| Numero di pagine | 6 |
| Rivista | BIOMEDICAL PAPERS OF THE THE FACULTY OF MEDICINE OF PALACKÝ UNIVERSITY, OLOMOUC CZECH REPUBLIC |
| Volume | 160 |
| Stato di pubblicazione | Published - 2016 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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The long-term effects of probiotics in the therapy of ulcerative colitis: a clinical study. / Lo Monte, Attilio Ignazio; Carini, Francesco; Tomasello, Giovanni; Romeo, Marcello; Damiano, Giuseppe; Marino Gammazza, Antonella; Palumbo, Vincenzo Davide; Buscemi, Salvatore; Damiani, Provvidenza; Lo Monte, Attilio Ignazio; Jurjus, Abdo; Carini, Francesco; Gammazza, Antonella Marino; Damiani, Provvidenza; Gerges-Geagea, Alice.
In: BIOMEDICAL PAPERS OF THE THE FACULTY OF MEDICINE OF PALACKÝ UNIVERSITY, OLOMOUC CZECH REPUBLIC, Vol. 160, 2016, pag. 372-377.Risultato della ricerca: Article
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TY - JOUR
T1 - The long-term effects of probiotics in the therapy of ulcerative colitis: a clinical study
AU - Lo Monte, Attilio Ignazio
AU - Carini, Francesco
AU - Tomasello, Giovanni
AU - Romeo, Marcello
AU - Damiano, Giuseppe
AU - Marino Gammazza, Antonella
AU - Palumbo, Vincenzo Davide
AU - Buscemi, Salvatore
AU - Damiani, Provvidenza
AU - Lo Monte, Attilio Ignazio
AU - Jurjus, Abdo
AU - Carini, Francesco
AU - Gammazza, Antonella Marino
AU - Damiani, Provvidenza
AU - Gerges-Geagea, Alice
PY - 2016
Y1 - 2016
N2 - Aim. Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity. Method. Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 patients received a single daily oral administration of mesalazine 1200 mg and a double daily administration of a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4. The treatment was carried out for two years and the clinical response evaluated according to the Modified Mayo Disease Activity Index. Results. All patients treated with combination therapy showed better improvement compared to the controls. In particular, the beneficial effects of probiotics were evident even after two years of treatment. Conclusions. A long-term treatment modality of anti-inflammatory drugs and probiotics is viable and could be an alternative to corticosteroids in mild-to moderate ulcerative colitis.
AB - Aim. Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity. Method. Sixty patients with moderate-to-severe ulcerative colitis were enrolled: 30 of them were treated with a single daily oral administration of mesalazine 1200 mg; 30 patients received a single daily oral administration of mesalazine 1200 mg and a double daily administration of a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4. The treatment was carried out for two years and the clinical response evaluated according to the Modified Mayo Disease Activity Index. Results. All patients treated with combination therapy showed better improvement compared to the controls. In particular, the beneficial effects of probiotics were evident even after two years of treatment. Conclusions. A long-term treatment modality of anti-inflammatory drugs and probiotics is viable and could be an alternative to corticosteroids in mild-to moderate ulcerative colitis.
UR - http://hdl.handle.net/10447/202597
UR - http://biomed.papers.upol.cz/doi/10.5507/bp.2016.044.pdf
M3 - Article
VL - 160
SP - 372
EP - 377
JO - Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
JF - Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
SN - 1213-8118
ER -