The janus face of NKT cell function in autoimmunity and infectious diseases

Guido Sireci, Giuliana Guggino, Marco Pio La Manna, Alessandra Torina, Marco Pio La Manna, Guido Sireci

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.
Lingua originaleEnglish
pagine (da-a)440-
Numero di pagine10
RivistaInternational Journal of Molecular Sciences
Volume19
Stato di pubblicazionePublished - 2018

Fingerprint

Janus
Natural Killer T-Cells
T-cells
infectious diseases
Autoimmunity
Communicable Diseases
cells
Adaptive Immunity
Antigens
CD1d Antigen
immunity
antigens
set theory
T-Lymphocytes
Antigen Receptors
Glycolipids
Autoantigens
T-Lymphocyte Subsets
Molecules
effectors

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Computer Science Applications
  • Spectroscopy
  • Molecular Biology

Cita questo

The janus face of NKT cell function in autoimmunity and infectious diseases. / Sireci, Guido; Guggino, Giuliana; La Manna, Marco Pio; Torina, Alessandra; La Manna, Marco Pio; Sireci, Guido.

In: International Journal of Molecular Sciences, Vol. 19, 2018, pag. 440-.

Risultato della ricerca: Article

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AU - Sireci, Guido

AU - Guggino, Giuliana

AU - La Manna, Marco Pio

AU - Torina, Alessandra

AU - La Manna, Marco Pio

AU - Sireci, Guido

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AB - Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.

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