7 Citazioni (Scopus)

Abstract

Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.
Lingua originaleEnglish
pagine (da-a)440-
Numero di pagine10
RivistaInternational Journal of Molecular Sciences
Volume19
Stato di pubblicazionePublished - 2018

Fingerprint

Janus
Natural Killer T-Cells
T-cells
infectious diseases
Autoimmunity
Communicable Diseases
cells
Adaptive Immunity
Antigens
CD1d Antigen
immunity
antigens
set theory
T-Lymphocytes
Antigen Receptors
Glycolipids
Autoantigens
T-Lymphocyte Subsets
Molecules
effectors

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo

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title = "The janus face of NKT cell function in autoimmunity and infectious diseases",
abstract = "Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.",
keywords = "Alpha-galactosylceramide, Autoimmunity, CD1d, Catalysis, Computer Science Applications1707 Computer Vision and Pattern Recognition, Glycolipids, Inorganic Chemistry, Microbes, Molecular Biology, NKT, Organic Chemistry, Physical and Theoretical Chemistry, Spectroscopy, Sulfatide",
author = "Giuliana Guggino and {La Manna}, {Marco Pio} and Guido Sireci and Alessandra Torina",
year = "2018",
language = "English",
volume = "19",
pages = "440--",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - The janus face of NKT cell function in autoimmunity and infectious diseases

AU - Guggino, Giuliana

AU - La Manna, Marco Pio

AU - Sireci, Guido

AU - Torina, Alessandra

PY - 2018

Y1 - 2018

N2 - Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.

AB - Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. These cells recognize self and microbial glycolipids bound to non-polymorphic and highly conserved CD1d molecules. Three NKT cell subsets, type I, II, and NKT-like expressing different antigen receptors (TCR) were described and TCR activation promotes intracellular events leading to specific functional activities. NKT can exhibit different functions depending on the secretion of soluble molecules and the interaction with other cell types. NKT cells act as regulatory cells in the defense against infections but, on the other hand, their effector functions can be involved in the pathogenesis of several inflammatory disorders due to their exposure to different microbial or self-antigens, respectively. A deep understanding of the biology and functions of type I, II, and NKT-like cells as well as their interplay with cell types acting in innate (neuthrophils, innate lymphoid cells, machrophages, and dendritic cells) and adaptive immunity (CD4+,CD8+, and double negative T cells) should be important to design potential immunotherapies for infectious and autoimmune diseases.

KW - Alpha-galactosylceramide

KW - Autoimmunity

KW - CD1d

KW - Catalysis

KW - Computer Science Applications1707 Computer Vision and Pattern Recognition

KW - Glycolipids

KW - Inorganic Chemistry

KW - Microbes

KW - Molecular Biology

KW - NKT

KW - Organic Chemistry

KW - Physical and Theoretical Chemistry

KW - Spectroscopy

KW - Sulfatide

UR - http://hdl.handle.net/10447/274685

UR - http://www.mdpi.com/1422-0067/19/2/440/pdf

M3 - Article

VL - 19

SP - 440-

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

ER -