The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study

Brigida Fierro, Giuseppe Cosentino, Filippo Brighina, Alvisi, De Icco, Bertino, Fresia, Berlangieri, Alfonsi, Moglia, Giorgio Sandrini, Luca Mainardi, Francesca Valentino

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Objective To investigate electrophysiologically the reproducibility of oropharyngeal swallowing in patients with ALS. Methods We enrolled 26 ALS patients, both with and without clinical signs of dysphagia, and 30 age-matched controls. The reproducibility of the electrophysiological signals related to the oral phase (electromyographic activity of the submental/suprahyoid muscles) and the pharyngeal phase (laryngeal-pharyngeal mechanogram) of swallowing across repeated swallows was assessed. To do this we computed two similarity indexes (SI) by using previously described mathematical algorithms. Results The reproducibility of oropharyngeal swallowing was significantly reduced both in patients with and in those without clinical signs of dysphagia, with more marked alterations being detected in the dysphagic group. The SI of both phases of swallowing, oral and pharyngeal, correlated significantly with dysphagia severity and disease severity. Conclusions In ALS different pathophysiological mechanisms can alter the stereotyped motor behaviors underlying normal swallowing, thus reducing the reproducibility of the swallowing act. A decrease in swallowing reproducibility could be a preclinical sign of dysphagia and, beyond a certain threshold, a pathological hallmark of oropharyngeal dysphagia. Significance Electrophysiological assessment is a simple and useful tool for the early detection of swallowing abnormalities, and for the management of overt dysphagia in ALS.
Lingua originaleEnglish
pagine (da-a)792-798
Numero di pagine7
RivistaDefault journal
Volume128
Stato di pubblicazionePublished - 2017

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Amyotrophic Lateral Sclerosis
Deglutition
Deglutition Disorders
Pharyngeal Muscles
Swallows
Stereotyped Behavior
Reproducibility of Results

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study. / Fierro, Brigida; Cosentino, Giuseppe; Brighina, Filippo; Alvisi; De Icco; Bertino; Fresia; Berlangieri; Alfonsi; Moglia; Sandrini, Giorgio; Mainardi, Luca; Valentino, Francesca.

In: Default journal, Vol. 128, 2017, pag. 792-798.

Risultato della ricerca: Article

Fierro, B, Cosentino, G, Brighina, F, Alvisi, De Icco, Bertino, Fresia, Berlangieri, Alfonsi, Moglia, Sandrini, G, Mainardi, L & Valentino, F 2017, 'The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study', Default journal, vol. 128, pagg. 792-798.
Fierro, Brigida ; Cosentino, Giuseppe ; Brighina, Filippo ; Alvisi ; De Icco ; Bertino ; Fresia ; Berlangieri ; Alfonsi ; Moglia ; Sandrini, Giorgio ; Mainardi, Luca ; Valentino, Francesca. / The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study. In: Default journal. 2017 ; Vol. 128. pagg. 792-798.
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title = "The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study",
abstract = "Objective To investigate electrophysiologically the reproducibility of oropharyngeal swallowing in patients with ALS. Methods We enrolled 26 ALS patients, both with and without clinical signs of dysphagia, and 30 age-matched controls. The reproducibility of the electrophysiological signals related to the oral phase (electromyographic activity of the submental/suprahyoid muscles) and the pharyngeal phase (laryngeal-pharyngeal mechanogram) of swallowing across repeated swallows was assessed. To do this we computed two similarity indexes (SI) by using previously described mathematical algorithms. Results The reproducibility of oropharyngeal swallowing was significantly reduced both in patients with and in those without clinical signs of dysphagia, with more marked alterations being detected in the dysphagic group. The SI of both phases of swallowing, oral and pharyngeal, correlated significantly with dysphagia severity and disease severity. Conclusions In ALS different pathophysiological mechanisms can alter the stereotyped motor behaviors underlying normal swallowing, thus reducing the reproducibility of the swallowing act. A decrease in swallowing reproducibility could be a preclinical sign of dysphagia and, beyond a certain threshold, a pathological hallmark of oropharyngeal dysphagia. Significance Electrophysiological assessment is a simple and useful tool for the early detection of swallowing abnormalities, and for the management of overt dysphagia in ALS.",
keywords = "ALS, Adult, Aged, Amyotrophic Lateral Sclerosis, Case-Control Studies, Deglutition, Deglutition Disorders, Dysphagia, Electromyography, Electrophysiological evaluation of swallowing, Female, Humans, Male, Middle Aged, Motor neuron disease, Neurology, Neurology (clinical), Pharynx, Physiology (medical), Reproducibility of Results, Sensory Systems, Similarity index",
author = "Brigida Fierro and Giuseppe Cosentino and Filippo Brighina and Alvisi and {De Icco} and Bertino and Fresia and Berlangieri and Alfonsi and Moglia and Giorgio Sandrini and Luca Mainardi and Francesca Valentino",
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T1 - The importance of the reproducibility of oropharyngeal swallowing in amyotrophic lateral sclerosis. An electrophysiological study

AU - Fierro, Brigida

AU - Cosentino, Giuseppe

AU - Brighina, Filippo

AU - Alvisi, null

AU - De Icco, null

AU - Bertino, null

AU - Fresia, null

AU - Berlangieri, null

AU - Alfonsi, null

AU - Moglia, null

AU - Sandrini, Giorgio

AU - Mainardi, Luca

AU - Valentino, Francesca

PY - 2017

Y1 - 2017

N2 - Objective To investigate electrophysiologically the reproducibility of oropharyngeal swallowing in patients with ALS. Methods We enrolled 26 ALS patients, both with and without clinical signs of dysphagia, and 30 age-matched controls. The reproducibility of the electrophysiological signals related to the oral phase (electromyographic activity of the submental/suprahyoid muscles) and the pharyngeal phase (laryngeal-pharyngeal mechanogram) of swallowing across repeated swallows was assessed. To do this we computed two similarity indexes (SI) by using previously described mathematical algorithms. Results The reproducibility of oropharyngeal swallowing was significantly reduced both in patients with and in those without clinical signs of dysphagia, with more marked alterations being detected in the dysphagic group. The SI of both phases of swallowing, oral and pharyngeal, correlated significantly with dysphagia severity and disease severity. Conclusions In ALS different pathophysiological mechanisms can alter the stereotyped motor behaviors underlying normal swallowing, thus reducing the reproducibility of the swallowing act. A decrease in swallowing reproducibility could be a preclinical sign of dysphagia and, beyond a certain threshold, a pathological hallmark of oropharyngeal dysphagia. Significance Electrophysiological assessment is a simple and useful tool for the early detection of swallowing abnormalities, and for the management of overt dysphagia in ALS.

AB - Objective To investigate electrophysiologically the reproducibility of oropharyngeal swallowing in patients with ALS. Methods We enrolled 26 ALS patients, both with and without clinical signs of dysphagia, and 30 age-matched controls. The reproducibility of the electrophysiological signals related to the oral phase (electromyographic activity of the submental/suprahyoid muscles) and the pharyngeal phase (laryngeal-pharyngeal mechanogram) of swallowing across repeated swallows was assessed. To do this we computed two similarity indexes (SI) by using previously described mathematical algorithms. Results The reproducibility of oropharyngeal swallowing was significantly reduced both in patients with and in those without clinical signs of dysphagia, with more marked alterations being detected in the dysphagic group. The SI of both phases of swallowing, oral and pharyngeal, correlated significantly with dysphagia severity and disease severity. Conclusions In ALS different pathophysiological mechanisms can alter the stereotyped motor behaviors underlying normal swallowing, thus reducing the reproducibility of the swallowing act. A decrease in swallowing reproducibility could be a preclinical sign of dysphagia and, beyond a certain threshold, a pathological hallmark of oropharyngeal dysphagia. Significance Electrophysiological assessment is a simple and useful tool for the early detection of swallowing abnormalities, and for the management of overt dysphagia in ALS.

KW - ALS

KW - Adult

KW - Aged

KW - Amyotrophic Lateral Sclerosis

KW - Case-Control Studies

KW - Deglutition

KW - Deglutition Disorders

KW - Dysphagia

KW - Electromyography

KW - Electrophysiological evaluation of swallowing

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Motor neuron disease

KW - Neurology

KW - Neurology (clinical)

KW - Pharynx

KW - Physiology (medical)

KW - Reproducibility of Results

KW - Sensory Systems

KW - Similarity index

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VL - 128

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EP - 798

JO - Default journal

JF - Default journal

ER -