The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

Walter Mazzucco; Claudia Cirilli; Massimo Vicentini; Manuel Zorzi; Roberto Rizzello; Michele Magoni; Walter Mazzucco; Francesco Tisano; Stefano Ferretti; Rosa Angela Filiberti; Giovanna Maria Sini; Cinzia Gasparotti; Arturo Iannelli; Pier Carlo Vercellino; Linda Guarda; Alessio Gili; Giuseppina Candela; Paolo Collarile; Stefano Rosso; Eugenia Spata; Anna Melcarne; Andreas Bulatko; Anna Clara Fanetti; Alessandra Ravaioli; Mario Usala; Rosanna Cusimano; Martina Taborelli; Carlotta Buzzoni; Simona Carone; Giulio Barigelletti; Elisabetta Borciani; Gemma Gola; Chiara Panato; Massimo Varvarà; Silvia Leite; Ivan Cometti; Katia Valla; Anna Luisa Caiazzo; Mario Fusco; Santo Scalzi; Francesca Gasparini; Giorgia Stoppa; Luciana Gatti; Fabio Pannozzo; Silvia Patriarca; Rosanna Cusimano; Giovanna Maria Sini; Gianfranco Manneschi; Maria Francesca Vitale; Adele Caldarella; Lucia Mangone; Luca Cavalieri D'Oro; Paolo Sgargi; Francesco Cuccaro; Susanna Busco; Luca Cavalieri D'Oro; Rosaria Cesaraccio; Anselmo Madeddu; Salvatore Vaccarella; Gianmaria Pennelli; Lucia Mangone; Silvano Piffer; Ugo Fedeli; Antonietta Torrisi; Giovanna Tagliabue; Antonella Puppo; Giuseppe Sampietro; Roberto Zanetti; Fabio Falcini; Luigino Dal Maso; Rosario Tumino; Diego Serraino; Guido Mazzoleni; Paolo Ricci; Silvia Franceschi; Antonio Giampiero Russo; Maria Michiara; Daniela Rita Pirino

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

Walter Mazzucco, Claudia Cirilli, Massimo Vicentini, Manuel Zorzi, Roberto Rizzello, Michele Magoni, Walter Mazzucco, Francesco Tisano, Stefano Ferretti, Rosa Angela Filiberti, Giovanna Maria Sini, Cinzia Gasparotti, Arturo Iannelli, Pier Carlo Vercellino, Linda Guarda, Alessio Gili, Giuseppina Candela, Paolo Collarile, Stefano Rosso, Eugenia SpataAnna Melcarne, Andreas Bulatko, Anna Clara Fanetti, Alessandra Ravaioli, Mario Usala, Rosanna Cusimano, Martina Taborelli, Carlotta Buzzoni, Simona Carone, Giulio Barigelletti, Elisabetta Borciani, Gemma Gola, Chiara Panato, Massimo Varvarà, Silvia Leite, Ivan Cometti, Katia Valla, Anna Luisa Caiazzo, Mario Fusco, Santo Scalzi, Francesca Gasparini, Giorgia Stoppa, Luciana Gatti, Fabio Pannozzo, Silvia Patriarca, Rosanna Cusimano, Giovanna Maria Sini, Gianfranco Manneschi, Maria Francesca Vitale, Adele Caldarella, Lucia Mangone, Luca Cavalieri D'Oro, Paolo Sgargi, Francesco Cuccaro, Susanna Busco, Luca Cavalieri D'Oro, Rosaria Cesaraccio, Anselmo Madeddu, Salvatore Vaccarella, Gianmaria Pennelli, Lucia Mangone, Silvano Piffer, Ugo Fedeli, Antonietta Torrisi, Giovanna Tagliabue, Antonella Puppo, Giuseppe Sampietro, Roberto Zanetti, Fabio Falcini, Luigino Dal Maso, Rosario Tumino, Diego Serraino, Guido Mazzoleni, Paolo Ricci, Silvia Franceschi, Antonio Giampiero Russo, Maria Michiara, Daniela Rita Pirino

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

33 Citazioni (Scopus)

Abstract

Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis.Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (þ91% in women, þ120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.a 2018 Elsevier Ltd. All rights reserved.

Lingua originale	English
pagine (da-a)	6-15
Numero di pagine	10
Rivista	European Journal of Cancer
Volume	94
Stato di pubblicazione	Published - 2018

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Mazzucco, W., Cirilli, C., Vicentini, M., Zorzi, M., Rizzello, R., Magoni, M., Mazzucco, W., Tisano, F., Ferretti, S., Filiberti, R. A., Sini, G. M., Gasparotti, C., Iannelli, A., Vercellino, P. C., Guarda, L., Gili, A., Candela, G., Collarile, P., Rosso, S., ... Pirino, D. R. (2018). The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012. European Journal of Cancer, 94, 6-15.

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012. / Mazzucco, Walter; Cirilli, Claudia; Vicentini, Massimo; Zorzi, Manuel; Rizzello, Roberto; Magoni, Michele; Mazzucco, Walter; Tisano, Francesco; Ferretti, Stefano; Filiberti, Rosa Angela; Sini, Giovanna Maria; Gasparotti, Cinzia; Iannelli, Arturo; Vercellino, Pier Carlo; Guarda, Linda; Gili, Alessio; Candela, Giuseppina; Collarile, Paolo; Rosso, Stefano; Spata, Eugenia; Melcarne, Anna; Bulatko, Andreas; Fanetti, Anna Clara; Ravaioli, Alessandra; Usala, Mario; Cusimano, Rosanna; Taborelli, Martina; Buzzoni, Carlotta; Carone, Simona; Barigelletti, Giulio; Borciani, Elisabetta; Gola, Gemma; Panato, Chiara; Varvarà, Massimo; Leite, Silvia; Cometti, Ivan; Valla, Katia; Caiazzo, Anna Luisa; Fusco, Mario; Scalzi, Santo; Gasparini, Francesca; Stoppa, Giorgia; Gatti, Luciana; Pannozzo, Fabio; Patriarca, Silvia; Cusimano, Rosanna; Sini, Giovanna Maria; Manneschi, Gianfranco; Vitale, Maria Francesca; Caldarella, Adele; Mangone, Lucia; D'Oro, Luca Cavalieri; Sgargi, Paolo; Cuccaro, Francesco; Busco, Susanna; D'Oro, Luca Cavalieri; Cesaraccio, Rosaria; Madeddu, Anselmo; Vaccarella, Salvatore; Pennelli, Gianmaria; Mangone, Lucia; Piffer, Silvano; Fedeli, Ugo; Torrisi, Antonietta; Tagliabue, Giovanna; Puppo, Antonella; Sampietro, Giuseppe; Zanetti, Roberto; Falcini, Fabio; Dal Maso, Luigino; Tumino, Rosario; Serraino, Diego; Mazzoleni, Guido; Ricci, Paolo; Franceschi, Silvia; Russo, Antonio Giampiero; Michiara, Maria; Pirino, Daniela Rita.

In: European Journal of Cancer, Vol. 94, 2018, pag. 6-15.

Risultato della ricerca: Article › peer review

Mazzucco, W, Cirilli, C, Vicentini, M, Zorzi, M, Rizzello, R, Magoni, M, Mazzucco, W, Tisano, F, Ferretti, S, Filiberti, RA, Sini, GM, Gasparotti, C, Iannelli, A, Vercellino, PC, Guarda, L, Gili, A, Candela, G, Collarile, P, Rosso, S, Spata, E, Melcarne, A, Bulatko, A, Fanetti, AC, Ravaioli, A, Usala, M, Cusimano, R, Taborelli, M, Buzzoni, C, Carone, S, Barigelletti, G, Borciani, E, Gola, G, Panato, C, Varvarà, M, Leite, S, Cometti, I, Valla, K, Caiazzo, AL, Fusco, M, Scalzi, S, Gasparini, F, Stoppa, G, Gatti, L, Pannozzo, F, Patriarca, S, Cusimano, R, Sini, GM, Manneschi, G, Vitale, MF, Caldarella, A, Mangone, L, D'Oro, LC, Sgargi, P, Cuccaro, F, Busco, S, D'Oro, LC, Cesaraccio, R, Madeddu, A, Vaccarella, S, Pennelli, G, Mangone, L, Piffer, S, Fedeli, U, Torrisi, A, Tagliabue, G, Puppo, A, Sampietro, G, Zanetti, R, Falcini, F, Dal Maso, L, Tumino, R, Serraino, D, Mazzoleni, G, Ricci, P, Franceschi, S, Russo, AG, Michiara, M & Pirino, DR 2018, 'The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012', European Journal of Cancer, vol. 94, pagg. 6-15.

Mazzucco, Walter ; Cirilli, Claudia ; Vicentini, Massimo ; Zorzi, Manuel ; Rizzello, Roberto ; Magoni, Michele ; Mazzucco, Walter ; Tisano, Francesco ; Ferretti, Stefano ; Filiberti, Rosa Angela ; Sini, Giovanna Maria ; Gasparotti, Cinzia ; Iannelli, Arturo ; Vercellino, Pier Carlo ; Guarda, Linda ; Gili, Alessio ; Candela, Giuseppina ; Collarile, Paolo ; Rosso, Stefano ; Spata, Eugenia ; Melcarne, Anna ; Bulatko, Andreas ; Fanetti, Anna Clara ; Ravaioli, Alessandra ; Usala, Mario ; Cusimano, Rosanna ; Taborelli, Martina ; Buzzoni, Carlotta ; Carone, Simona ; Barigelletti, Giulio ; Borciani, Elisabetta ; Gola, Gemma ; Panato, Chiara ; Varvarà, Massimo ; Leite, Silvia ; Cometti, Ivan ; Valla, Katia ; Caiazzo, Anna Luisa ; Fusco, Mario ; Scalzi, Santo ; Gasparini, Francesca ; Stoppa, Giorgia ; Gatti, Luciana ; Pannozzo, Fabio ; Patriarca, Silvia ; Cusimano, Rosanna ; Sini, Giovanna Maria ; Manneschi, Gianfranco ; Vitale, Maria Francesca ; Caldarella, Adele ; Mangone, Lucia ; D'Oro, Luca Cavalieri ; Sgargi, Paolo ; Cuccaro, Francesco ; Busco, Susanna ; D'Oro, Luca Cavalieri ; Cesaraccio, Rosaria ; Madeddu, Anselmo ; Vaccarella, Salvatore ; Pennelli, Gianmaria ; Mangone, Lucia ; Piffer, Silvano ; Fedeli, Ugo ; Torrisi, Antonietta ; Tagliabue, Giovanna ; Puppo, Antonella ; Sampietro, Giuseppe ; Zanetti, Roberto ; Falcini, Fabio ; Dal Maso, Luigino ; Tumino, Rosario ; Serraino, Diego ; Mazzoleni, Guido ; Ricci, Paolo ; Franceschi, Silvia ; Russo, Antonio Giampiero ; Michiara, Maria ; Pirino, Daniela Rita. / The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012. In: European Journal of Cancer. 2018 ; Vol. 94. pagg. 6-15.

@article{6cb9040b81d64ce0897e7f8d59f266e2,

title = "The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012",

abstract = "Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis.Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC ({\th}91% in women, {\th}120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.a 2018 Elsevier Ltd. All rights reserved.",

author = "Walter Mazzucco and Claudia Cirilli and Massimo Vicentini and Manuel Zorzi and Roberto Rizzello and Michele Magoni and Walter Mazzucco and Francesco Tisano and Stefano Ferretti and Filiberti, {Rosa Angela} and Sini, {Giovanna Maria} and Cinzia Gasparotti and Arturo Iannelli and Vercellino, {Pier Carlo} and Linda Guarda and Alessio Gili and Giuseppina Candela and Paolo Collarile and Stefano Rosso and Eugenia Spata and Anna Melcarne and Andreas Bulatko and Fanetti, {Anna Clara} and Alessandra Ravaioli and Mario Usala and Rosanna Cusimano and Martina Taborelli and Carlotta Buzzoni and Simona Carone and Giulio Barigelletti and Elisabetta Borciani and Gemma Gola and Chiara Panato and Massimo Varvar{\`a} and Silvia Leite and Ivan Cometti and Katia Valla and Caiazzo, {Anna Luisa} and Mario Fusco and Santo Scalzi and Francesca Gasparini and Giorgia Stoppa and Luciana Gatti and Fabio Pannozzo and Silvia Patriarca and Rosanna Cusimano and Sini, {Giovanna Maria} and Gianfranco Manneschi and Vitale, {Maria Francesca} and Adele Caldarella and Lucia Mangone and D'Oro, {Luca Cavalieri} and Paolo Sgargi and Francesco Cuccaro and Susanna Busco and D'Oro, {Luca Cavalieri} and Rosaria Cesaraccio and Anselmo Madeddu and Salvatore Vaccarella and Gianmaria Pennelli and Lucia Mangone and Silvano Piffer and Ugo Fedeli and Antonietta Torrisi and Giovanna Tagliabue and Antonella Puppo and Giuseppe Sampietro and Roberto Zanetti and Fabio Falcini and {Dal Maso}, Luigino and Rosario Tumino and Diego Serraino and Guido Mazzoleni and Paolo Ricci and Silvia Franceschi and Russo, {Antonio Giampiero} and Maria Michiara and Pirino, {Daniela Rita}",

year = "2018",

language = "English",

volume = "94",

pages = "6--15",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

AU - Mazzucco, Walter

AU - Cirilli, Claudia

AU - Vicentini, Massimo

AU - Zorzi, Manuel

AU - Rizzello, Roberto

AU - Magoni, Michele

AU - Mazzucco, Walter

AU - Tisano, Francesco

AU - Ferretti, Stefano

AU - Filiberti, Rosa Angela

AU - Sini, Giovanna Maria

AU - Gasparotti, Cinzia

AU - Iannelli, Arturo

AU - Vercellino, Pier Carlo

AU - Guarda, Linda

AU - Gili, Alessio

AU - Candela, Giuseppina

AU - Collarile, Paolo

AU - Rosso, Stefano

AU - Spata, Eugenia

AU - Melcarne, Anna

AU - Bulatko, Andreas

AU - Fanetti, Anna Clara

AU - Ravaioli, Alessandra

AU - Usala, Mario

AU - Cusimano, Rosanna

AU - Taborelli, Martina

AU - Buzzoni, Carlotta

AU - Carone, Simona

AU - Barigelletti, Giulio

AU - Borciani, Elisabetta

AU - Gola, Gemma

AU - Panato, Chiara

AU - Varvarà, Massimo

AU - Leite, Silvia

AU - Cometti, Ivan

AU - Valla, Katia

AU - Caiazzo, Anna Luisa

AU - Fusco, Mario

AU - Scalzi, Santo

AU - Gasparini, Francesca

AU - Stoppa, Giorgia

AU - Gatti, Luciana

AU - Pannozzo, Fabio

AU - Patriarca, Silvia

AU - Cusimano, Rosanna

AU - Sini, Giovanna Maria

AU - Manneschi, Gianfranco

AU - Vitale, Maria Francesca

AU - Caldarella, Adele

AU - Mangone, Lucia

AU - D'Oro, Luca Cavalieri

AU - Sgargi, Paolo

AU - Cuccaro, Francesco

AU - Busco, Susanna

AU - D'Oro, Luca Cavalieri

AU - Cesaraccio, Rosaria

AU - Madeddu, Anselmo

AU - Vaccarella, Salvatore

AU - Pennelli, Gianmaria

AU - Mangone, Lucia

AU - Piffer, Silvano

AU - Fedeli, Ugo

AU - Torrisi, Antonietta

AU - Tagliabue, Giovanna

AU - Puppo, Antonella

AU - Sampietro, Giuseppe

AU - Zanetti, Roberto

AU - Falcini, Fabio

AU - Dal Maso, Luigino

AU - Tumino, Rosario

AU - Serraino, Diego

AU - Mazzoleni, Guido

AU - Ricci, Paolo

AU - Franceschi, Silvia

AU - Russo, Antonio Giampiero

AU - Michiara, Maria

AU - Pirino, Daniela Rita

PY - 2018

Y1 - 2018

N2 - Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis.Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (þ91% in women, þ120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.a 2018 Elsevier Ltd. All rights reserved.

AB - Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis.Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (þ91% in women, þ120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.a 2018 Elsevier Ltd. All rights reserved.

UR - http://hdl.handle.net/10447/279511

M3 - Article

VL - 94

SP - 6

EP - 15

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

ER -

The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998-2012

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