The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998e2012

Walter Mazzucco, Claudia Cirilli, Massimo Vicentini, Manuel Zorzi, Roberto Rizzello, Michele Magoni, Francesco Tisano, Stefano Ferretti, Rosa Angela Filiberti, Cinzia Gasparotti, Arturo Iannelli, Pier Carlo Vercellino, Linda Guarda, Alessio Gili, Giuseppina Candela, Paolo Collarile, Stefano Rosso, Eugenia Spata, Anna Melcarne, Andreas BulatkoAnna Clara Fanetti, Alessandra Ravaioli, Mario Usala, Rosanna Cusimano, Martina Taborelli, Carlotta Buzzoni, Simona Carone, Giulio Barigelletti, Elisabetta Borciani, Gemma Gola, Chiara Panato, Massimo Varvarà, Silvia Leite, Ivan Cometti, Katia Valla, Anna Luisa Caiazzo, Mario Fusco, Santo Scalzi, Francesca Gasparini, Giorgia Stoppa, Luciana Gatti, Fabio Pannozzo, Silvia Patriarca, Giovanna Maria Sini, Gianfranco Manneschi, Maria Francesca Vitale, Adele Caldarella, Paolo Sgargi, Francesco Cuccaro, Susanna Busco, Luca Cavalieri D'Oro, Rosaria Cesaraccio, Anselmo Madeddu, Salvatore Vaccarella, Gianmaria Pennelli, Lucia Mangone, Silvano Piffer, Ugo Fedeli, Antonietta Torrisi, Giovanna Tagliabue, Antonella Puppo, Giuseppe Sampietro, Roberto Zanetti, Fabio Falcini, Luigino Dal Maso, Rosario Tumino, Diego Serraino, Guido Mazzoleni, Paolo Ricci, Silvia Franceschi, Antonio Giampiero Russo, Maria Michiara, Daniela Rita Pirino

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13 Citazioni (Scopus)

Abstract

Aims: In Italy, incidence rates of thyroid cancer (TC) are among the highest world- wide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attribut- able to overdiagnosis.Methods: Data on TC cases reported to Italian cancer registries during 1998e2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. Results: In Italy between 1998e2002 and 2008e2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (þ91% in women, þ120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998e2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008e2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders.Conclusion(s): Incidence rates of TC are steadily increasing in Italy and largely due to over- diagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.a 2018 Elsevier Ltd. All rights reserved.
Lingua originaleEnglish
pagine (da-a)6-15
Numero di pagine10
RivistaEuropean Journal of Cancer
Volume94
Stato di pubblicazionePublished - 2018

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Mazzucco, W., Cirilli, C., Vicentini, M., Zorzi, M., Rizzello, R., Magoni, M., Tisano, F., Ferretti, S., Filiberti, R. A., Gasparotti, C., Iannelli, A., Vercellino, P. C., Guarda, L., Gili, A., Candela, G., Collarile, P., Rosso, S., Spata, E., Melcarne, A., ... Pirino, D. R. (2018). The impact of overdiagnosis on thyroid cancer epidemic in Italy,1998e2012. European Journal of Cancer, 94, 6-15.