TY - JOUR
T1 - The immunohistochemical peptidergic expression of leptin is associated with recurrence of malignancy in laryngeal squamous cell carcinoma.
AU - Leone, Angelo
AU - Tessitore, Vincenzo
AU - Uzzo, Maria Laura
AU - Gallina, Salvatore
AU - Spatola, Giovanni Francesco
AU - Costantino, Claudio
AU - Bonaventura, Giuseppe
AU - Speciale, Riccardo
AU - Di Benedetto, Denise Valentina
AU - Marchese, Donatella
AU - Sireci, Federico
AU - Lorusso, Francesco
AU - Napoli, Giuseppe
PY - 2015
Y1 - 2015
N2 - Leptin is a peptide that plays a key role in the control of satiety, energy expenditure, food intake and various reproductive processes. In the last years, the expression of leptin had been found in malignant cells of various origins. The aim of this study is to evaluate leptin expression in human laryngeal squamous cell carcinoma (SCC) and to investigate its possible role in predicting prognosis. Leptin expression was determined by immunohistochemistry in pathological and healthy tissue specimens from 24 patients with laryngeal SCC. Specimens were stained with an anti-leptin antibody. All measurements were performed using a computer-based image analysis system and scale of staining intensity was determined. All tumoural specimens showed significant immunoreactivity for leptin compared to healthy tissues (p ⤠0.05), but showed different immunoreactivity that was related to clinicopathological features. High leptin expression was not significantly related with TNM, histological grading (HG) or advanced (II and IV) clinical stage (p > 0.05). Recurrence of malignancy was found to be significantly related with high expression of leptin by Spearmanâs rank correlation test (r = 0.59; p = 0.002), Fisherâs test (p = 0.017) and Kaplan- Meier product-limit estimate (Log-rank test, p ⤠0.05). In particular, multivariate logistic regression analysis showed that recurrences were significantly related with nodal involvement, HG and leptin expression (p ⤠0.05). These preliminary results suggest that leptin may be a valuable parameter for predicting prognosis in laryngeal SCC.
AB - Leptin is a peptide that plays a key role in the control of satiety, energy expenditure, food intake and various reproductive processes. In the last years, the expression of leptin had been found in malignant cells of various origins. The aim of this study is to evaluate leptin expression in human laryngeal squamous cell carcinoma (SCC) and to investigate its possible role in predicting prognosis. Leptin expression was determined by immunohistochemistry in pathological and healthy tissue specimens from 24 patients with laryngeal SCC. Specimens were stained with an anti-leptin antibody. All measurements were performed using a computer-based image analysis system and scale of staining intensity was determined. All tumoural specimens showed significant immunoreactivity for leptin compared to healthy tissues (p ⤠0.05), but showed different immunoreactivity that was related to clinicopathological features. High leptin expression was not significantly related with TNM, histological grading (HG) or advanced (II and IV) clinical stage (p > 0.05). Recurrence of malignancy was found to be significantly related with high expression of leptin by Spearmanâs rank correlation test (r = 0.59; p = 0.002), Fisherâs test (p = 0.017) and Kaplan- Meier product-limit estimate (Log-rank test, p ⤠0.05). In particular, multivariate logistic regression analysis showed that recurrences were significantly related with nodal involvement, HG and leptin expression (p ⤠0.05). These preliminary results suggest that leptin may be a valuable parameter for predicting prognosis in laryngeal SCC.
KW - Laryngeal carcinoma
KW - Leptin
KW - Malignancy recurrence
KW - Otorhinolaryngology2734 Pathology and Forensic Medicine
KW - Laryngeal carcinoma
KW - Leptin
KW - Malignancy recurrence
KW - Otorhinolaryngology2734 Pathology and Forensic Medicine
UR - http://hdl.handle.net/10447/251846
UR - http://www.actaitalica.it/issues/2015/1-2015/03-Gallina.pdf
M3 - Article
VL - 35
SP - 15
EP - 22
JO - Acta Otorhinolaryngologica Italica
JF - Acta Otorhinolaryngologica Italica
SN - 0392-100X
ER -