The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans

Claudia Colomba, Anna Aiello, Calogero Caruso, Giulia Accardi, Giuseppina Candore, Mattia Emanuela Ligotti, Janardan P. Pandey, Massimo Bilancia, Danilo Di Bona, Luigi Macchia, Giovanni Duro, Sergio Rizzo

Risultato della ricerca: Article

Abstract

Hepatitis B virus (HBV) infection causes a self-limiting disease in most individuals. However, < 10% of infected subjects develop a chronic disease. Genetic host variability of polymorphic genes at the interface of innate and acquired immunity, such as killer immunoglobulin-like receptors (KIR), their human leucocyte antigen (HLA) and IgG allotypes (GM), could explain this different clinical picture. We previously showed a protective role of the KIR2DL3 gene for the development of chronic hepatitis B (CHB), and a detrimental role of the KIR ligand groups, HLA-A-Bw4 and HLA-C2. We have expanded the previous analysis genotyping patients for GM23 and GM3/17 allotypes. The comparison of the patients with CHB with those who resolved HBV infection showed that the presence of GM17 allele virtually eliminated the risk of developing CHB (OR, 0·03; 95% CI, 0·004–0·16; P < 0·0001). In addition, the combination of GM17, KIR2DL3, HLA-A-Bw4 and HLA-C2 was highly sensitive to predict the outcome of HBV infection.
Lingua originaleEnglish
pagine (da-a)178-182
Numero di pagine5
RivistaImmunology
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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