THE FINGERPRINT OF THE HUMAN GASTROINTESTINAL TRACT MICROBIOTA: A HYPOTHESIS OF MOLECULAR MAPPING

Giovanni Tomasello, Francesco Cappello, Angelo Leone, Francesco Carini, Zeenny, Margherita Mazzola, Alice Gerges Geagea, Tomasello, Jurjus, Cappello

Risultato della ricerca: Article

5 Citazioni (Scopus)

Abstract

The precise etiology of Inflammatory Bowel Disease (IBD) remains unclear and several factors are believed to play a role in its development and progression, including the composition of microbial communities resident in the gastrointestinal tract. Human intestinal microbiota are extensive with at least 15.000-36.000 bacterial species. However, thanks to the new development in sequencing and molecular taxonomic methodologies, our understanding of the microbiota population composition, dynamics, and ecology has greatly increased. Intestinal microbiota play a critical role in the maintenance of the host intestinal barrier homeostasis, while dysbiosis, which involves reduction in the microbiome diversity, can lead to progression of the inflammatory disorders, such as IBD and colorectal cancer. It is hypothesized that fingerprinting characterization of the microbiota community composition is the first step in the study of this complex bacterial ecosystem and a crucial step in the targeted therapy. Molecular fingerprinting of human gastrointestinal tract microbiota could be performed by different techniques including the semi quantitation, 16srRNA, the DNA-microarray as well as other relatively new methods which were developed to study many complex bacterial ecosystem. These techniques provide individual data of the human intestinal microbiota and provide estimation of the relative presence of the microbial target groups within each individual. such personalized information serves as a remarkable and unprecedented opportunity to improve targeted medical treatment and probably develop strategies to prfevent disease.
Lingua originaleEnglish
pagine (da-a)245-249
Numero di pagine5
RivistaDefault journal
Volume31
Stato di pubblicazionePublished - 2017

Fingerprint

Dermatoglyphics
Gastrointestinal Tract
Microbiota
Inflammatory Bowel Diseases
Ecosystem
Dysbiosis
Population Dynamics
Ecology
Oligonucleotide Array Sequence Analysis
Colorectal Neoplasms
Homeostasis
Maintenance
Gastrointestinal Microbiome
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research

Cita questo

THE FINGERPRINT OF THE HUMAN GASTROINTESTINAL TRACT MICROBIOTA: A HYPOTHESIS OF MOLECULAR MAPPING. / Tomasello, Giovanni; Cappello, Francesco; Leone, Angelo; Carini, Francesco; Zeenny; Mazzola, Margherita; Gerges Geagea, Alice; Tomasello; Jurjus; Cappello.

In: Default journal, Vol. 31, 2017, pag. 245-249.

Risultato della ricerca: Article

Tomasello, Giovanni ; Cappello, Francesco ; Leone, Angelo ; Carini, Francesco ; Zeenny ; Mazzola, Margherita ; Gerges Geagea, Alice ; Tomasello ; Jurjus ; Cappello. / THE FINGERPRINT OF THE HUMAN GASTROINTESTINAL TRACT MICROBIOTA: A HYPOTHESIS OF MOLECULAR MAPPING. In: Default journal. 2017 ; Vol. 31. pagg. 245-249.
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abstract = "The precise etiology of Inflammatory Bowel Disease (IBD) remains unclear and several factors are believed to play a role in its development and progression, including the composition of microbial communities resident in the gastrointestinal tract. Human intestinal microbiota are extensive with at least 15.000-36.000 bacterial species. However, thanks to the new development in sequencing and molecular taxonomic methodologies, our understanding of the microbiota population composition, dynamics, and ecology has greatly increased. Intestinal microbiota play a critical role in the maintenance of the host intestinal barrier homeostasis, while dysbiosis, which involves reduction in the microbiome diversity, can lead to progression of the inflammatory disorders, such as IBD and colorectal cancer. It is hypothesized that fingerprinting characterization of the microbiota community composition is the first step in the study of this complex bacterial ecosystem and a crucial step in the targeted therapy. Molecular fingerprinting of human gastrointestinal tract microbiota could be performed by different techniques including the semi quantitation, 16srRNA, the DNA-microarray as well as other relatively new methods which were developed to study many complex bacterial ecosystem. These techniques provide individual data of the human intestinal microbiota and provide estimation of the relative presence of the microbial target groups within each individual. such personalized information serves as a remarkable and unprecedented opportunity to improve targeted medical treatment and probably develop strategies to prfevent disease.",
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