The current work is an in silico study of data from previous publications and genome browsers, on the origin of the humansynteny HSA7a/16p. The molecular composition of the chromosomal segments identified as HSA7a/16 and 7b (free or differentlyassociated) is not yet clear. This means that a syntenic association 7/16, which can be detected by an in situ hybridization(FISH) method in different taxa, may not necessarily correspond to those of the same association in differentlineages. In silico research, together with comparative cytogenetics, have been applied in order to define the composition ofthe 7/16 syntenic association. These results allow a confident reconstruction of the syntenic associations HSA7/16 indiverse vertebrate lineages, indicating various levels of homology, but also considerable levels of non-homology, whichshould elicit caution with phylogenetic interpretations. The 7/16 association represents a paradigmatic example of thecomplexity involved in the interpretation of comparative cytogenetic data from a phylogenetic perspective.
|Numero di pagine||0|
|Stato di pubblicazione||Published - 2013|
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