Abstract
| Lingua originale | English |
|---|---|
| pagine (da-a) | 50-65 |
| Numero di pagine | 16 |
| Rivista | AGEING RESEARCH REVIEWS |
| Volume | 29 |
| Stato di pubblicazione | Published - 2016 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Neurology
- Molecular Biology
- Ageing
- Biochemistry
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The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases. / Caruso, Calogero; Balistreri, Carmela Rita; Madonna, Rosalinda; Melino, Gerry.
In: AGEING RESEARCH REVIEWS, Vol. 29, 2016, pag. 50-65.Risultato della ricerca: Article
}
TY - JOUR
T1 - The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases
AU - Caruso, Calogero
AU - Balistreri, Carmela Rita
AU - Madonna, Rosalinda
AU - Melino, Gerry
PY - 2016
Y1 - 2016
N2 - Notch signaling is an evolutionarily conserved pathway, which is fundamental for the development of all tissues, organs and systems of human body. Recently, a considerable and still growing number of studies have highlighted the contribution of Notch signaling in various pathological processes of the adult life, such as age-related diseases. In particular, the Notch pathway has emerged as major player in the maintenance of tissue specific homeostasis, through the control of proliferation, migration, phenotypes and functions of tissue cells, as well as in the cross-talk between inflammatory cells and the innate immune system, and in onset of inflammatory age-related diseases. However, until now there is a confounding evidence about the related mechanisms. Here, we discuss mechanisms through which Notch signaling acts in a very complex network of pathways, where it seems to have the crucial role of hub. Thus, we stress the possibility to use Notch pathway, the related molecules and pathways constituting this network, both as innovative (predictive, diagnostic and prognostic) biomarkers and targets for personalised treatments for age-related diseases.
AB - Notch signaling is an evolutionarily conserved pathway, which is fundamental for the development of all tissues, organs and systems of human body. Recently, a considerable and still growing number of studies have highlighted the contribution of Notch signaling in various pathological processes of the adult life, such as age-related diseases. In particular, the Notch pathway has emerged as major player in the maintenance of tissue specific homeostasis, through the control of proliferation, migration, phenotypes and functions of tissue cells, as well as in the cross-talk between inflammatory cells and the innate immune system, and in onset of inflammatory age-related diseases. However, until now there is a confounding evidence about the related mechanisms. Here, we discuss mechanisms through which Notch signaling acts in a very complex network of pathways, where it seems to have the crucial role of hub. Thus, we stress the possibility to use Notch pathway, the related molecules and pathways constituting this network, both as innovative (predictive, diagnostic and prognostic) biomarkers and targets for personalised treatments for age-related diseases.
KW - Age-related diseases; Ageing; Biomarkers and targets for personalized treatments; Involved mechanisms; Notch pathway; a signaling complex network
UR - http://hdl.handle.net/10447/180096
M3 - Article
VL - 29
SP - 50
EP - 65
JO - AGEING RESEARCH REVIEWS
JF - AGEING RESEARCH REVIEWS
SN - 1872-9649
ER -