The effect of bergamot on dyslipidemia

Dragana Nikolic, Rosaria Vincenza Giglio, Manfredi Rizzo, Angelo Maria Patti, Giuseppe Montalto, Angelo Maria Patti, Niki Katsiki, Dimitri P. Mikhailidis, Khalid Al-Rasadi, Rosaria Vincenza Giglio, Manfredi Rizzo, Ekaterina Ivanova, Giovanni Li Volti, Alexander N. Orekhov, Manfredi Rizzo

Risultato della ricerca: Articlepeer review

18 Citazioni (Scopus)


Background Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
Lingua originaleEnglish
pagine (da-a)1175-1181
Numero di pagine7
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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