The degree of urinary hypercortisolism is not correlated with the severity of cushing’s syndrome

Marco Calogero Amato, Roberto Citarrella, Alessandro Ciresi, Valentina Guarnotta, Carla Giordano, Annamaria Colao, Laura Trementino, Chiara Simeoli, Davide Iacuaniello, Giorgio Arnaldi, Grazia Michetti, Rosario Pivonello

Risultato della ricerca: Articlepeer review

28 Citazioni (Scopus)


Cushing syndrome (CS) is characterized by increased morbidity and mortality compared to the general population. However, there are patients who have moreclinical aggressive forms than others. Aim of the study is to evaluate whether the degree of hypercortisolism, defined by the number of times urinary free cortisol (UFC) levels exceed the upper limit of the normal range (ULN), is related to the worsening of phenotypic features, as well as metabolic and cardiovascular parameters, in a cohort of CS patients. A cross-sectional study was conducted on 192 patients with active CS, consecutively presenting at the outpatients’ clinic of the University Hospitals of Ancona, Naples, and Palermo. Patients were grouped into mild (UFC not exceeding twice the ULN), moderate (2–5 times the ULN), and severe (more than 5 times the ULN) hypercortisolism. Thirty-sevenpatients (19.3 %) had mild, 115 (59.8 %) moderate, and 40 (20.9 %) severe hypercortisolism. A significant trend of increase among the three groups was demonstrated for 8-, 16-, and 24-h serum cortisol levels (p.001) and serum cortisol after low dose of dexamethasone suppression test(p = 0.001). No significant trend of increase was found regarding phenotype and comorbidities. The degree of hypercortisolism by itself does not appear to be a sufficient parameter to express the severity of CS. Therefore, estimating the severity of CS according to biochemical parametersremains a challenge, while the clinical phenotype and the associated comorbidities might be more useful to assessing the severity of the CS.
Lingua originaleEnglish
pagine (da-a)564-572
Numero di pagine9
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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