The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Viviana Barra, Viviana Barra, Fachinetti

Risultato della ricerca: Article

30 Citazioni (Scopus)

Abstract

Centromeres are the chromosomal domains required to ensure faithful transmission of the genome during cell division. They have a central role in preventing aneuploidy, by orchestrating the assembly of several components required for chromosome separation. However, centromeres also adopt a complex structure that makes them susceptible to being sites of chromosome rearrangements. Therefore, preservation of centromere integrity is a difficult, but important task for the cell. In this review, we discuss how centromeres could potentially be a source of genome instability and how centromere aberrations and rearrangements are linked with human diseases such as cancer.
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaNature Communications
Volume9
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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