The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation

Mario Barbagallo, Ligia Juliana Dominguez Rodriguez, Elpidio Santillo, Gallucci, Cinzia Giuli, Luca Fallavollita, Stefanelli, Stefania Maggi, Stefania Maggi, Francesca Sorvillo, Stefano Eleuteri, Monica Migale, Monia Francavilla, Francesca Pastore, Pastore, Giulia Maria Falaschi, Giulia Maria Falaschi, Giovanna Di Bella, Lavinia Toussan, Lavinia ToussanPaola Cheli, Ilenia Macchiati, Rita Del Pinto, Michelangela Barbieri, Luciano Marini, Proietti, Valeria Ludovici, Sara Rotunno, Roberto Brunelli, Edith Angellotti, Maurizio Cassol, Maurizio Cassol, Antonella Proietti, Proietti, Maria Grazia Oddo, Silvia Santini, Rosaria D’Urso, Giovambattista Desideri, Giovambattista Desideri, Stefania Maggi, Valentino Culotta, Maurizio Gallucci, Maurizio Gallucci, Letizia Petricca, Antonella Proietti, Claudio Ferri, Manuela Stefanelli, Silvia Santini, Paolo Falaschi, Demetrio Postacchini, Patrizia Cardelli, Giovambattista Desideri, Francesca Pastore, Giuseppe Paolisso, Mario Barbagallo, Falaschi, Stefania Maggi, Maggi, Luca Fallavollita, Antonio Martocchia, Paolo Falaschi, Mario Barbagallo, Maurizio Gallucci, Stefania Maggi, Maggi, Stefania Maggi, Maggi, Qwrri, Stefanelli, Silvia Santini, Silvia Santini, Marianna Noale, Noale, Demetrio Postacchini, Postacchini, Patrizia Cardelli, Antonio Martocchia, Antonio Martocchia, Paolo Falaschi, Falaschi, Mario Barbagallo, Giuseppe Paolisso, Claudio Ferri, Ligia J. Dominguez, Manuela Stefanelli, Carlo Ferrigno, Carmela D'Urso, Fabio Pastorella, Giulia Carmen Gallucci, Maurizio Barbieri, Paolo Proietti, Ulderico Brunelli

Risultato della ricerca: Articlepeer review

3 Citazioni (Scopus)


Background: Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders. Aims: To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol). Methods: From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged > 65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine). Results: In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7 ± 145.5 and 173.7 ± 118.1 (mean ± standard deviation) μg/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 ± 92.7 and 144.1 ± 82.3 μg/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p = 0.05, female patients with MetS vs female patients without MetS, p < 0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r = 0.187 (p < 0.025) and r = 0.411 (p < 0.00000001), respectively. Discussion: The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects. Conclusion: The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
Lingua originaleEnglish
Numero di pagine7
RivistaAging clinical and experimental research
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2717???


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