THE COMPLEX INTERPLAY BETWEEN VITAMIN D DEFICIENCY AND DIABETES

Emanuele Sinagra, Attilio Ignazio Lo Monte, Vincenzo Davide Palumbo, Francesco Damiani, Alida Abruzzo, Calogero Camma', Giovanni Tomasello, Francesco Cappello, Giuseppe Damiano, Dario Raimondo, Emanuele Sinagra, Chiara Genco, Fabio Salvatore Macaluso, Vincenzo Davide Palumbo, Calogero Cammà, Francesco Cappello

Risultato della ricerca: Article

Abstract

It has been recently highlighted the link between vitamin D and metabolic and immunological pro- cesses, which established its role as an essential component of human health preservation. Vitamin D has been defined as natural immune modulators, and through the activation of its receptors (VDRs), it regulates calcium metabolism, cellular growth, proliferation and apoptosis, and other immunological functions. In this setting, vita- min D has also been reported to influence glucose regulation via effects on insulin secretion and action. Vitamin D deficiency is strongly associated with obesity mostly due to the storage of vitamin D in adipose tissue because of its lipophilic properties. The decrease in vitamin D levels may occur through several mechanisms such as a decrease in the calcium concentration, an increase in PTH, or a direct effect of vitamin D on worsening insulin resistance and secretion, augmenting the risk of developing type 2 diabetes. On the other hand, retrospective analysis and observational studies demonstrated high prevalence of vitamin D deficiency in patients with type 1 diabetes and suggested a contributory role in the pathogenesis of type 1 diabetes, specially with certain allelic variations of the VDR. Vitamin D supplementation during pregnancy and early childhood decreased the risk of autoimmune dia- betes and perhaps, even after the onset of diabetes, it may improve glycemic control. In addition, in subjects that are affected by a high risk of developing diabetes (impaired fasting glucose and/or glucose tolerance, possibly without obesity) vitamin D supplementation could be helpful on the prevention of type 2 diabetes
Lingua originaleEnglish
pagine (da-a)3-14
Numero di pagine12
RivistaProgress in Nutrition
Volume17
Stato di pubblicazionePublished - 2015

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vitamin D deficiency
Vitamin D Deficiency
vitamin D
Vitamin D
diabetes
insulin-dependent diabetes mellitus
Type 1 Diabetes Mellitus
insulin secretion
noninsulin-dependent diabetes mellitus
Glucose
Type 2 Diabetes Mellitus
obesity
Obesity
Calcium
calcium
glycemic control
glucose
risk reduction
observational studies
glucose tolerance

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cita questo

THE COMPLEX INTERPLAY BETWEEN VITAMIN D DEFICIENCY AND DIABETES. / Sinagra, Emanuele; Lo Monte, Attilio Ignazio; Palumbo, Vincenzo Davide; Damiani, Francesco; Abruzzo, Alida; Camma', Calogero; Tomasello, Giovanni; Cappello, Francesco; Damiano, Giuseppe; Raimondo, Dario; Sinagra, Emanuele; Genco, Chiara; Macaluso, Fabio Salvatore; Palumbo, Vincenzo Davide; Cammà, Calogero; Cappello, Francesco.

In: Progress in Nutrition, Vol. 17, 2015, pag. 3-14.

Risultato della ricerca: Article

Sinagra, Emanuele ; Lo Monte, Attilio Ignazio ; Palumbo, Vincenzo Davide ; Damiani, Francesco ; Abruzzo, Alida ; Camma', Calogero ; Tomasello, Giovanni ; Cappello, Francesco ; Damiano, Giuseppe ; Raimondo, Dario ; Sinagra, Emanuele ; Genco, Chiara ; Macaluso, Fabio Salvatore ; Palumbo, Vincenzo Davide ; Cammà, Calogero ; Cappello, Francesco. / THE COMPLEX INTERPLAY BETWEEN VITAMIN D DEFICIENCY AND DIABETES. In: Progress in Nutrition. 2015 ; Vol. 17. pagg. 3-14.
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abstract = "It has been recently highlighted the link between vitamin D and metabolic and immunological pro- cesses, which established its role as an essential component of human health preservation. Vitamin D has been defined as natural immune modulators, and through the activation of its receptors (VDRs), it regulates calcium metabolism, cellular growth, proliferation and apoptosis, and other immunological functions. In this setting, vita- min D has also been reported to influence glucose regulation via effects on insulin secretion and action. Vitamin D deficiency is strongly associated with obesity mostly due to the storage of vitamin D in adipose tissue because of its lipophilic properties. The decrease in vitamin D levels may occur through several mechanisms such as a decrease in the calcium concentration, an increase in PTH, or a direct effect of vitamin D on worsening insulin resistance and secretion, augmenting the risk of developing type 2 diabetes. On the other hand, retrospective analysis and observational studies demonstrated high prevalence of vitamin D deficiency in patients with type 1 diabetes and suggested a contributory role in the pathogenesis of type 1 diabetes, specially with certain allelic variations of the VDR. Vitamin D supplementation during pregnancy and early childhood decreased the risk of autoimmune dia- betes and perhaps, even after the onset of diabetes, it may improve glycemic control. In addition, in subjects that are affected by a high risk of developing diabetes (impaired fasting glucose and/or glucose tolerance, possibly without obesity) vitamin D supplementation could be helpful on the prevention of type 2 diabetes",
author = "Emanuele Sinagra and {Lo Monte}, {Attilio Ignazio} and Palumbo, {Vincenzo Davide} and Francesco Damiani and Alida Abruzzo and Calogero Camma' and Giovanni Tomasello and Francesco Cappello and Giuseppe Damiano and Dario Raimondo and Emanuele Sinagra and Chiara Genco and Macaluso, {Fabio Salvatore} and Palumbo, {Vincenzo Davide} and Calogero Camm{\`a} and Francesco Cappello",
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AU - Damiani, Francesco

AU - Abruzzo, Alida

AU - Camma', Calogero

AU - Tomasello, Giovanni

AU - Cappello, Francesco

AU - Damiano, Giuseppe

AU - Raimondo, Dario

AU - Sinagra, Emanuele

AU - Genco, Chiara

AU - Macaluso, Fabio Salvatore

AU - Palumbo, Vincenzo Davide

AU - Cammà, Calogero

AU - Cappello, Francesco

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