The chimeric ALT-vastus lateralis free flap in reconstruction of advanced BRONJ of the maxilla.

Santanelli Di Pompeo, F

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Introduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disor- ders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with dis- ease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed unevent- fully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.
Lingua originaleEnglish
pagine (da-a)191-196
Numero di pagine6
RivistaEuroMediterranean Biomedical Journal
Volume10
Stato di pubblicazionePublished - 2015

Fingerprint

Free Tissue Flaps
Quadriceps Muscle
Maxilla
Debridement
Osteonecrosis
Diphosphonates
Jaw
Therapeutics
Tissue Donors
Morbidity
Bone and Bones
Pharmaceutical Preparations

Cita questo

The chimeric ALT-vastus lateralis free flap in reconstruction of advanced BRONJ of the maxilla. / Santanelli Di Pompeo, F.

In: EuroMediterranean Biomedical Journal, Vol. 10, 2015, pag. 191-196.

Risultato della ricerca: Article

@article{3a848e298c804befa4be383541a66c9f,
title = "The chimeric ALT-vastus lateralis free flap in reconstruction of advanced BRONJ of the maxilla.",
abstract = "Introduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disor- ders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with dis- ease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed unevent- fully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.",
author = "{Santanelli Di Pompeo, F} and Adriana Cordova and Salvatore D'Arpa and {Di Lorenzo}, Sara and Francesca Toia and Michele Cillino",
year = "2015",
language = "English",
volume = "10",
pages = "191--196",
journal = "EuroMediterranean Biomedical Journal",
issn = "2279-7165",
publisher = "EuroMediterranean Biomedical Journal",

}

TY - JOUR

T1 - The chimeric ALT-vastus lateralis free flap in reconstruction of advanced BRONJ of the maxilla.

AU - Santanelli Di Pompeo, F

AU - Cordova, Adriana

AU - D'Arpa, Salvatore

AU - Di Lorenzo, Sara

AU - Toia, Francesca

AU - Cillino, Michele

PY - 2015

Y1 - 2015

N2 - Introduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disor- ders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with dis- ease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed unevent- fully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.

AB - Introduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a dangerous complication of bisphosphonates, a class of pharmaceutical agents used in numerous bone disor- ders. No gold standard therapy exists, but recent literature suggests that, in advanced stages, the best results are achieved with aggressive debridement. In this paper, we report our experience of treatment of stage 3 BRONJ of the maxilla with extensive surgical debridement and reconstruction with a chimeric ALT-Vastus lateralis flap. Methods Five selected patients with stage 3 BRONJ underwent partial maxillectomy with dis- ease-free margins followed by immediate reconstruction with a chimeric ALT-Vastus lateralis free flap. Results Only two patients experienced minor complications. All other patients healed unevent- fully within two weeks and donor site morbidity was minimal. Conclusions Our data suggest that aggressive debridement and reconstruction with a chimeric ALT -Vastus lateralis flap is an effective option for the treatment of stage III BRONJ of the maxilla.

UR - http://hdl.handle.net/10447/151899

UR - http://www.embj.org/images/ISSUE_2015/Toia_16.pdf

M3 - Article

VL - 10

SP - 191

EP - 196

JO - EuroMediterranean Biomedical Journal

JF - EuroMediterranean Biomedical Journal

SN - 2279-7165

ER -