The changes of lipid metabolism in advanced renal cell carcinoma patients treated with everolimus: A new pharmacodynamic marker?

Antonio Russo, Cinzia Ortega, Francesco Pantano, Luca Galli, Elena Verzoni, Roberto Iacovelli, Marianna Silletta, Annamaria Rauco, Francesco Maria Guida, Stefano Cascinu, Camillo Porta, Mimma Rizzo, Matteo Santoni, Alessandro Conti, Daniela Modica, Valentina Ballatore, Francesco Maria Guida, Francesco Maria Guida, Antonio Lugini, Giovanni SchinzariGiacomo Carteni, Giuseppe Procopio, Pierfilippo Crucitti, Michele Milella, Giuseppe Tonini, Daniele Santini, Alessandra Felici, Daniele Santini

Risultato della ricerca: Articlepeer review

8 Citazioni (Scopus)

Abstract

Background: Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved for the treatment of metastatic renal cell carcinoma (mRCC). We aimed to assess the association between the baseline values and treatmentrelated modifications of total serum cholesterol (C), triglycerides (T), body mass index (BMI), fasting blood glucose level (FBG) and blood pressure (BP) levels and the outcome of patients treated with everolimus for mRCC. Methods: 177 patients were included in this retrospective analysis. Time to progression (TTP), clinical benefit (CB) and overall survival (OS) were evaluated. Results: Basal BMI was significantly higher in patients who experienced a CB (p=0,0145). C, T and C +T raises were significantly associated with baseline BMI (p=0.0412, 0.0283 and 0.0001). Median TTP was significantly longer in patients with T raise compared to patients without T (10 vs 6, p =0.030), C (8 vs 5, p =0.042) and C+T raise (10.9 vs 5.0, p=0.003). At the multivariate analysis, only C+T increase was associated with improved TTP (p=0.005). T raise (21.0 vs 14.0, p=0.002) and C+T increase (21.0 vs 14.0, p=0.006) were correlated with improved OS but were not significant at multivariate analysis. Conclusion: C+T raise is an early predictor for everolimus efficacy for patients with mRCC.
Lingua originaleEnglish
Numero di pagine0
RivistaPLoS One
Volume10
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • General

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