The challenging riddle about the janus‐type role of hsp60 and related extracellular vesicles and miRNAs in carcinogenesis and the promises of its solution

Celeste Caruso Bavisotto, Giuseppe Vergilio, Federica Scalia, Alessandra Maria Vitale, Alessandro Pitruzzella, Sabrina David, Alessandro Pitruzzella, Alberto Fucarino, Federica Scalia, Celeste Caruso Bavisotto, Alessandra Maria Vitale, Everly Conway De Macario, Alberto J. L. Macario

Risultato della ricerca: Articlepeer review

Abstract

Hsp60 is one of the most ancient and evolutionarily conserved members of the chaperoning system. It typically resides within mitochondria, in which it contributes to maintaining the organelle’s proteome integrity and homeostasis. In the last few years, it has been shown that Hsp60 also occurs in other locations, intracellularly and extracellularly, including cytosol, plasmacell membrane, and extracellular vesicles (EVs). Consequently, non‐canonical functions and interacting partners of Hsp60 have been identified and it has been realized that it is a hub molecule in diverse networks and pathways and that it is implicated, directly or indirectly, in the development of various pathological conditions, the Hsp60 chaperonopathies. In this review, we will focus on the multi‐faceted role of this chaperonin in human cancers, showing the contribution of intra‐ and extracellular Hsp60 in cancer development and progression, as well as the impact of miRNA‐mediated regulation of Hsp60 in carcinogenesis. There are still various aspects of this intricate biological scenario that are poorly understood but ongoing research is steadily providing new insights and we will direct attention to them. For instance, we will highlight the possible applications of the Hsp60 involvement in carcinogenesis not only in diagnosis, but also in the development of specific anti‐cancer therapies centered on the use of the chaperonin as therapeutic target or agent and depending on its role, pro‐ or anti‐tumor.
Lingua originaleEnglish
pagine (da-a)1-18
Numero di pagine18
RivistaAPPLIED SCIENCES
Volume11
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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  • Instrumentation
  • ???subjectarea.asjc.2200.2200???
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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