The association of grip strength with depressive symptoms and cortisol in hair: A cross-sectional study of older adults

Nicola Veronese, Pinar Soysal, Nicola Veronese, Lee Smith, Igor Grabovac, Joseph Firth, Lin Yang, Sarah E. Jackson, Ai Koyanagi, Brendon Stubbs

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Background: Low handgrip strength has been shown to be associated with higher levels of depressive symptoms. One area of mental health that is understudied in relation to grip strength is chronic stress, which can exist independently to depression, or as a comorbidity or precursor to this condition. The present study examined cross-sectional associations between grip strength, an established marker of physical function, and (a) depressive symptoms and (b) chronic stress utilizing hair cortisol concentrations, while accounting for multiple pertinent confounding variables. Method: Data were used from wave 6 (2012/13) of the English Longitudinal Study of Aging, a panel study of older (≥50 years) community-dwelling men and women. Grip strength was measured in kg using a hand-held dynamometer. Depressive symptoms were assessed using the 8-item Center for Epidemiologic Studies Depression scale. Hair cortisol concentrations (pg/mg) were determined from samples of scalp hair and log-transformed for analysis to correct skewness. Associations of grip strength with depressive symptoms and hair cortisol concentration were tested using linear regression models adjusted for age, sex, ethnicity, wealth, smoking status, physical activity, body mass index, limiting long-standing illness, arthritis, diabetes, and hair treatment. Results: The sample comprised of 3741 participants (mean age 68.4 years, 66.4% female). After adjustment for age and sex, grip strength was significantly and negatively associated with both depressive symptoms (B = −0.038, SE = 0.004, P < 0.001) and hair cortisol (B = −0.003, SE = 0.001, P = 0.029). However, in the fully-adjusted models, both associations were attenuated and only the association with depressive symptoms remained statistically significant (B = −0.015, SE = 0.004, P < 0.001; hair cortisol B = −0.002, SE = 0.001, P = 0.088). Conclusion: In a large sample of older adults in England, grip strength was negatively associated with depressive symptoms. Results were inconclusive regarding the association between grip strength and chronic stress. Further research examining the longitudinal relationships between muscular strength and specific aspects of mental health, while also exploring the neurobiological mechanisms underlying these associations, is warranted before recommendations for policy and practice can be made. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Lingua originaleEnglish
pagine (da-a)1604-1609
Numero di pagine6
RivistaSCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
Volume29
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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