The anemonia viridis venom: Coupling biochemical purification and rna-seq for translational research

Matteo Cammarata, Paolo Colombo, Yaroslav Andreev, Aldo Nicosia, Alexander Mikov, Angela Cuttitta, Sergey Kozlov, Aldo Nicosia, Angela Cuttitta

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1 Citazioni (Scopus)

Abstract

Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops. Strikingly, cnidaria are considered as sustainable resources for this purpose, as they possess unique cells for attack and protection, producing an articulated cocktail of bioactive substances. The Mediterranean sea anemone Anemonia viridis has been studied extensively for years. In this short review, we summarize advances in bioprospecting of the A. viridis toxin arsenal. A. viridis RNA datasets and toxin data mining approaches are briefly described. Analysis reveals the major pool of neurotoxins of A. viridis, which are particularly active on sodium and potassium channels. This review therefore integrates progress in both RNA-Seq based and biochemical-based bioprospecting of A. viridis toxins for biotechnological exploitation.
Lingua originaleEnglish
pagine (da-a)407-
Numero di pagine15
RivistaMarine Drugs
Volume16
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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    Cammarata, M., Colombo, P., Andreev, Y., Nicosia, A., Mikov, A., Cuttitta, A., Kozlov, S., Nicosia, A., & Cuttitta, A. (2018). The anemonia viridis venom: Coupling biochemical purification and rna-seq for translational research. Marine Drugs, 16, 407-.