Abstract

Familial combined hyperlipidemia (FCHL) is the most frequent genetic hyperlipidemia. FHCL is associated with high prevalence of cardiovascular disease. In this study we selected 208 patients affected by FHCL and evaluated the efficacy of the lipid-lowering statin therapy using different statins available in the market. The results show that the percent of patients reaching the therapeutic goal ranges from 19.7 % (LDL-C <100 mg/dL) to 50.9% (LDL-C <130 mg/dL) and from 16.9 % (non HDL-C <130 mg/dL) to 46.6 % (non HDL-C <160 mg/dL) according to the different ATPIII-NCEP-guidelines cut offs. In conclusion the statin monotherapy is only partly effective in the management of FCHL therapy
Lingua originaleItalian
pagine (da-a)123-129
Numero di pagine7
RivistaTrends in Medicine
Volume7
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Pharmacology (medical)

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@article{9257d49c5eea4ecdb047d1f4d895e0f1,
title = "TERAPIA CON STATINE IN PAZIENTI SICILIANI AFFETTI DA IPERLIPIDEMIA FAMILIARE COMBINATA",
abstract = "Familial combined hyperlipidemia (FCHL) is the most frequent genetic hyperlipidemia. FHCL is associated with high prevalence of cardiovascular disease. In this study we selected 208 patients affected by FHCL and evaluated the efficacy of the lipid-lowering statin therapy using different statins available in the market. The results show that the percent of patients reaching the therapeutic goal ranges from 19.7 {\%} (LDL-C <100 mg/dL) to 50.9{\%} (LDL-C <130 mg/dL) and from 16.9 {\%} (non HDL-C <130 mg/dL) to 46.6 {\%} (non HDL-C <160 mg/dL) according to the different ATPIII-NCEP-guidelines cut offs. In conclusion the statin monotherapy is only partly effective in the management of FCHL therapy",
author = "Gueli, {Maria Concetta} and Alberto Notarbartolo and Salvatore Amato and Barbagallo, {Carlo Maria} and Maurizio Averna and Cefalu', {Angelo Baldassare} and Alessandra Foresta and Emanuela Fertitta and Marina Pomilla and Francesca Fayer and Averna, {Maurizio R.}",
year = "2007",
language = "Italian",
volume = "7",
pages = "123--129",
journal = "Trends in Medicine",
issn = "1594-2848",
publisher = "Pharma Project Group Edizioni Scientifiche (PPG)",

}

TY - JOUR

T1 - TERAPIA CON STATINE IN PAZIENTI SICILIANI AFFETTI DA IPERLIPIDEMIA FAMILIARE COMBINATA

AU - Gueli, Maria Concetta

AU - Notarbartolo, Alberto

AU - Amato, Salvatore

AU - Barbagallo, Carlo Maria

AU - Averna, Maurizio

AU - Cefalu', Angelo Baldassare

AU - Foresta, Alessandra

AU - Fertitta, Emanuela

AU - Pomilla, Marina

AU - Fayer, Francesca

AU - Averna, Maurizio R.

PY - 2007

Y1 - 2007

N2 - Familial combined hyperlipidemia (FCHL) is the most frequent genetic hyperlipidemia. FHCL is associated with high prevalence of cardiovascular disease. In this study we selected 208 patients affected by FHCL and evaluated the efficacy of the lipid-lowering statin therapy using different statins available in the market. The results show that the percent of patients reaching the therapeutic goal ranges from 19.7 % (LDL-C <100 mg/dL) to 50.9% (LDL-C <130 mg/dL) and from 16.9 % (non HDL-C <130 mg/dL) to 46.6 % (non HDL-C <160 mg/dL) according to the different ATPIII-NCEP-guidelines cut offs. In conclusion the statin monotherapy is only partly effective in the management of FCHL therapy

AB - Familial combined hyperlipidemia (FCHL) is the most frequent genetic hyperlipidemia. FHCL is associated with high prevalence of cardiovascular disease. In this study we selected 208 patients affected by FHCL and evaluated the efficacy of the lipid-lowering statin therapy using different statins available in the market. The results show that the percent of patients reaching the therapeutic goal ranges from 19.7 % (LDL-C <100 mg/dL) to 50.9% (LDL-C <130 mg/dL) and from 16.9 % (non HDL-C <130 mg/dL) to 46.6 % (non HDL-C <160 mg/dL) according to the different ATPIII-NCEP-guidelines cut offs. In conclusion the statin monotherapy is only partly effective in the management of FCHL therapy

UR - http://hdl.handle.net/10447/15645

M3 - Article

VL - 7

SP - 123

EP - 129

JO - Trends in Medicine

JF - Trends in Medicine

SN - 1594-2848

ER -