Temporal structure of the rat’s behavior in elevated plus maze test

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47 Citazioni (Scopus)

Abstract

Aim of the research was to evaluate, by means of quantitative and multivariate temporal pattern analyses,the behavior of Wistar rat in elevated plus maze (EPM) test. On the basis of an ethogram encompassing24 behavioral elements, quantitative results showed that 130.14±8.01 behavioral elements occurredin central platform and in closed arms (protected zones), whereas 88.62±6.04 occurred in open arms(unprotected zones). Percent distribution was characterized by a prevalence of sniffing, walking andvertical exploration. Analysis of minute-by-minute duration evidenced a decrease for time spent in openarms and central platform and an increase for time spent in closed arms. As to multivariate t-patternanalysis, 126 different temporal patterns were detected. Behavioral stripes, summarizing distribution ofsuch t-patterns along time, showed that several t-patterns were not homogeneously distributed alongthe test observational period: t-patterns encompassing behavioral events occurring prevalently in centralplatform-open arms were observed during the first minutes, whereas t-patterns structured on the basis ofevents occurring mainly in central platform-closed arms were detected during the last minutes. Therefore,during the observation in elevated plus maze, rat’s behavior undergoes significant rearrangements ofits temporal features. Present research demonstrates, for the first time, the existence of complex andsignificantly timed behavioral sequences in the activity of Wistar rats tested in elevated plus maze.Application of t-pattern analysis can provide useful tools to characterize the behavioral dynamics ofanxiety-related rodent behavior and differentiate the effect of various anxioselective substances.
Lingua originaleEnglish
pagine (da-a)290-299
Numero di pagine10
RivistaBehavioural Brain Research
Volume237
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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