Taste receptors, innate immunity and longevity: the case of TAS2R16 gene

Giulia Accardi, Calogero Caruso, Mattia Emanuela Ligotti, Giuseppina Candore, Anna Aiello, Riccardo Bellazzi, Alberto Malovini, Francesco Villa, Riccardo Bellazzi, Anna Maciag, Annibale A. Puca

Risultato della ricerca: Article

2 Citazioni (Scopus)

Abstract

Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune response plays a key role in the attainment of longevity, it is not surprising that the rs978739 polymorphism of the bitter taste receptor TAS2R16 gene has been shown to be associated with longevity in a population of 941 individuals ranging in age from 20 to 106 years from Calabria (Italy). There are many possible candidate genes for human longevity, however of the many genes tested, only APOE and FOXO3 survived to association in replication studies. So, it is necessary to validate in other studies genes proposed to be associated with longevity. Thus, we analysed the association of the quoted polymorphism in a population of long lived individuals (LLIs) and controls from another Italian population from Cilento.
Lingua originaleEnglish
Numero di pagine0
RivistaIMMUNITY & AGEING
Volume16
Stato di pubblicazionePublished - 2019

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Innate Immunity
Genes
Population
Respiratory Tract Infections
Italy
Signal Transduction

All Science Journal Classification (ASJC) codes

  • Immunology
  • Ageing

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Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. / Accardi, Giulia; Caruso, Calogero; Ligotti, Mattia Emanuela; Candore, Giuseppina; Aiello, Anna; Bellazzi, Riccardo; Malovini, Alberto; Villa, Francesco; Bellazzi, Riccardo; Maciag, Anna; Puca, Annibale A.

In: IMMUNITY & AGEING, Vol. 16, 2019.

Risultato della ricerca: Article

Accardi, Giulia ; Caruso, Calogero ; Ligotti, Mattia Emanuela ; Candore, Giuseppina ; Aiello, Anna ; Bellazzi, Riccardo ; Malovini, Alberto ; Villa, Francesco ; Bellazzi, Riccardo ; Maciag, Anna ; Puca, Annibale A. / Taste receptors, innate immunity and longevity: the case of TAS2R16 gene. In: IMMUNITY & AGEING. 2019 ; Vol. 16.
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AU - Accardi, Giulia

AU - Caruso, Calogero

AU - Ligotti, Mattia Emanuela

AU - Candore, Giuseppina

AU - Aiello, Anna

AU - Bellazzi, Riccardo

AU - Malovini, Alberto

AU - Villa, Francesco

AU - Bellazzi, Riccardo

AU - Maciag, Anna

AU - Puca, Annibale A.

PY - 2019

Y1 - 2019

N2 - Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune response plays a key role in the attainment of longevity, it is not surprising that the rs978739 polymorphism of the bitter taste receptor TAS2R16 gene has been shown to be associated with longevity in a population of 941 individuals ranging in age from 20 to 106 years from Calabria (Italy). There are many possible candidate genes for human longevity, however of the many genes tested, only APOE and FOXO3 survived to association in replication studies. So, it is necessary to validate in other studies genes proposed to be associated with longevity. Thus, we analysed the association of the quoted polymorphism in a population of long lived individuals (LLIs) and controls from another Italian population from Cilento.

AB - Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune response plays a key role in the attainment of longevity, it is not surprising that the rs978739 polymorphism of the bitter taste receptor TAS2R16 gene has been shown to be associated with longevity in a population of 941 individuals ranging in age from 20 to 106 years from Calabria (Italy). There are many possible candidate genes for human longevity, however of the many genes tested, only APOE and FOXO3 survived to association in replication studies. So, it is necessary to validate in other studies genes proposed to be associated with longevity. Thus, we analysed the association of the quoted polymorphism in a population of long lived individuals (LLIs) and controls from another Italian population from Cilento.

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