Targeting angiogenesis in biliary tract cancers: An open option

Antonio Russo, Vito Longo, Domenico Ribatti, Marc Peeters, Oronzo Brunetti, Valeria Simone, Michele Simone, Aldo Scarpa, Christian Rolfo, Amalia Azzariti, Nicola Silvestris, Mario Testini, Luigi Lupo, Eugenio Maiorano, Christian Diego Rolfo, Michele De Simone

Risultato della ricerca: Article

15 Citazioni (Scopus)

Abstract

Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), are involved in the angiogenesis process and their expression on tumor samples has been explored as prognostic marker in both cholangiocarcinoma and gallbladder cancer. Recent studies evaluated the genomic landscape of BTCs and evidenced that aberrations in several genes enrolled in the pro-angiogenic signaling, such as FGF receptor-2 (FGFR-2), are characteristic of BTCs. New drugs targeting the signaling pathways involved in angiogenesis have been tested in preclinical studies both in vitro and in vivo with promising results. Moreover, several clinical studies tested monoclonal antibodies against VEGF and tyrosine kinase inhibitors targeting the VEGF and the MEK/ERK pathways. Herein, we evaluate both the pathogenic mechanisms of BTCs focused on angiogenesis and the preclinical and clinical data available regarding the use of new anti-angiogenic drugs in these malignancies.
Lingua originaleEnglish
Numero di pagine0
RivistaInternational Journal of Molecular Sciences
Volume18
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cita questo

Russo, A., Longo, V., Ribatti, D., Peeters, M., Brunetti, O., Simone, V., Simone, M., Scarpa, A., Rolfo, C., Azzariti, A., Silvestris, N., Testini, M., Lupo, L., Maiorano, E., Rolfo, C. D., & De Simone, M. (2017). Targeting angiogenesis in biliary tract cancers: An open option. International Journal of Molecular Sciences, 18.