Targeted Therapies in Hepatocellular Carcinoma

Alberto Firenze, Giuseppe Cicero, Vito Di Marco, Antonio Russo, Eugenio Fiorentino, Fabrizio Bronte, Giuseppe Bronte, Russo, Cusenza, Bronte, Fontana, Cicero, Christian Rolfo, Gioacchino Angarano, Giuseppe Bronte, Enrico Bronte, Stefania Cusenza

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

The onset of hepatocellular carcinoma (HCC) is related to the development of non-neoplastic liver disease, such as viral infections and cirrhosis. Even though patients with chronic liver diseases undergo clinical surveillance for early diagnosis of HCC, this cancer is often diagnosed in advanced stage. In this case locoregional treatment is not possible and systemic therapies are the best way to control it. Until now sorafenib, a Raf and multi-kinase inhibitor has been the best, choice to treat HCC systemically. It showed a survival benefit in multicenter phase III trials. However the proper patient setting to treat is not well defined, since the results in Child-Pugh B patients are conflicting. To date various new target drugs are under developed and other biological treatments normally indicated in other malignancies are under investigation also for HCC. These strategies aim to target the different biological pathways implicated in HCC development and progression. The target drugs studied in HCC include anti-VEGF and anti-EGFR monoclonal antibodies, tyrosine kinase inhibitors and mTOR inhibitors. The most important challenge is represented by the best integration of these drugs with standard treatments to achieve improvement in overall survival and quality of life.
Lingua originaleEnglish
pagine (da-a)966-974
Numero di pagine9
RivistaCurrent Medicinal Chemistry
Volume21
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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