TACE versus TAE as therapy for hepatocellular carcinoma.

Vincenza Calvaruso, Laura Marelli, Manousou Pinelopi, Giacomo Germani, Maria Misseri, Vincenza Calvaruso, Maria Pleguezuelo, Elias Xiruochakis, Maria Misseri, Andrew K. Burroughs

Risultato della ricerca: Articlepeer review

66 Citazioni (Scopus)

Abstract

Transarterial chemoembolization (TACE) improves survival in cirrhotic patients with hepatocellular carcinoma (HCC). The optimal schedule, best anticancer agent and best technique are still unclear. TACE may not be better than transarterial embolization (TAE). HCC is very chemoresistant, thus embolization may be more important than chemotherapy. Lipiodol cannot be considered as an embolic agent and there are no data to show that it can release chemotherapeutic agents slowly. It can mask residual vascularity on CT imaging and its use is not recommended. Both TACE and TAE result in hypoxia, which stimulates angiogenesis, promoting tumor growth; thus combination of TACE with antiangiogenic agents may improve current results. To date, there is no evidence that TACE pre-liver transplantation or resection helps to expand current selection criteria for patients with HCC, nor results in less recurrence after surgery. Combination with other techniques, such as radiofrequency ablation and drugs, may enhance the effect of TACE. New trials are being conducted to clarify these issues.
Lingua originaleEnglish
Numero di pagine19
RivistaExpert Review of Anticancer Therapy
Volume2008
Stato di pubblicazionePublished - 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology (medical)

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