Synthesis, Structural Analysis, Fiber Formation and Preliminary Anticancer Characterization of the Organotin Polyether from Dibutyltin Dichloride and 2,5-Dimethyl-3-hexyne-2,5-diol

Lorenzo Pellerito, Tiziana Fiore, Claudia Pellerito, Michelangelo Scopelliti, Michael R. Roner, Lorenzo Pellerito, Charles E. Carraher Jr., Girish Barot, Kimberly Shahi

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Abstract

The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65% yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-O are present and bands characteristic of the Sn-Cl are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusters to greater than 300 units are found. The products offer outstanding inhibition of a wide range of cancer cell lines showing inhibition of prostate, breast, and colon human cancer cell lines. The product spontaneously forms fibers. Mossbauer results are consistent with the fibers existing in a very constrained molecular environment and being present in about 50% of the product consistent with that visually observed.
Lingua originaleEnglish
pagine (da-a)371-386
Numero di pagine16
RivistaJOURNAL OF POLYMER MATERIALS
Volume29
Stato di pubblicazionePublished - 2012

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Polyethers
Structural analysis
Ions
Fibers
Cells
Tin
Chain length
Polymerization
dibutyldichlorotin

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

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@article{c1f8b344e9764e1ebe0c425d79c77aee,
title = "Synthesis, Structural Analysis, Fiber Formation and Preliminary Anticancer Characterization of the Organotin Polyether from Dibutyltin Dichloride and 2,5-Dimethyl-3-hexyne-2,5-diol",
abstract = "The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65{\%} yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-O are present and bands characteristic of the Sn-Cl are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusters to greater than 300 units are found. The products offer outstanding inhibition of a wide range of cancer cell lines showing inhibition of prostate, breast, and colon human cancer cell lines. The product spontaneously forms fibers. Mossbauer results are consistent with the fibers existing in a very constrained molecular environment and being present in about 50{\%} of the product consistent with that visually observed.",
author = "Lorenzo Pellerito and Tiziana Fiore and Claudia Pellerito and Michelangelo Scopelliti and Roner, {Michael R.} and Lorenzo Pellerito and {Carraher Jr.}, {Charles E.} and Girish Barot and Kimberly Shahi",
year = "2012",
language = "English",
volume = "29",
pages = "371--386",
journal = "JOURNAL OF POLYMER MATERIALS",
issn = "0973-8622",

}

TY - JOUR

T1 - Synthesis, Structural Analysis, Fiber Formation and Preliminary Anticancer Characterization of the Organotin Polyether from Dibutyltin Dichloride and 2,5-Dimethyl-3-hexyne-2,5-diol

AU - Pellerito, Lorenzo

AU - Fiore, Tiziana

AU - Pellerito, Claudia

AU - Scopelliti, Michelangelo

AU - Roner, Michael R.

AU - Pellerito, Lorenzo

AU - Carraher Jr., Charles E.

AU - Barot, Girish

AU - Shahi, Kimberly

PY - 2012

Y1 - 2012

N2 - The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65% yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-O are present and bands characteristic of the Sn-Cl are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusters to greater than 300 units are found. The products offer outstanding inhibition of a wide range of cancer cell lines showing inhibition of prostate, breast, and colon human cancer cell lines. The product spontaneously forms fibers. Mossbauer results are consistent with the fibers existing in a very constrained molecular environment and being present in about 50% of the product consistent with that visually observed.

AB - The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65% yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-O are present and bands characteristic of the Sn-Cl are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusters to greater than 300 units are found. The products offer outstanding inhibition of a wide range of cancer cell lines showing inhibition of prostate, breast, and colon human cancer cell lines. The product spontaneously forms fibers. Mossbauer results are consistent with the fibers existing in a very constrained molecular environment and being present in about 50% of the product consistent with that visually observed.

UR - http://hdl.handle.net/10447/75215

M3 - Article

VL - 29

SP - 371

EP - 386

JO - JOURNAL OF POLYMER MATERIALS

JF - JOURNAL OF POLYMER MATERIALS

SN - 0973-8622

ER -