Novel mononuclear complexes of Pt(II), cis-[PtCl2(DMSO)HL] 2DMSO (1), where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid and Pt(bdt)Cl2 (2), where bdt = [2,4-bis(5,6-diphenyl-1,2,4-triazin-3yl)-pyridine] have been synthesized and characterized by elemental analysis,IR and 1H NMR spectroscopy and X-ray crystallography diffraction analyses. The molecular structure of(1) shows that Pt(II) ion has a square planar geometry with N(3) bonded heterocycle ligand, two cis chlorideanions and S-bonded dimethylsulfoxide. The antiproliferative activity of complexes (1) and (2) hasbeen tested in vitro against HepG2 human hepatoma cells and non-malignant human-derived hepaticcells (Chang). Complex (1), cis-[PtCl2(DMSO)HL] 2DMSO, was effective inducer of apoptotic death onHepG2 cells and its cytotoxic activity was higher than that exerted by cisplatin. Apoptosis effect wasassociated with externalization of plasma membrane phosphatidylserine.
|Numero di pagine||7|
|Rivista||Inorganica Chimica Acta|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry
Rubino, S., Di Stefano, V., Tesoriere, L., Girasolo, M. A., Orecchio, S., Stocco, G., Bruno, G., Nicolò, & Attanzio, A. (2014). Synthesis, spectroscopic characterization and antiproliferative activity of two platinum(II) complexes containing N-donor heterocycles. Inorganica Chimica Acta, 418, 112-118.