Synthesis, spectroscopic characterization and antiproliferative activity of two platinum(II) complexes containing N-donor heterocycles

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Abstract

Novel mononuclear complexes of Pt(II), cis-[PtCl2(DMSO)HL] 2DMSO (1), where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid and Pt(bdt)Cl2 (2), where bdt = [2,4-bis(5,6-diphenyl-1,2,4-triazin-3yl)-pyridine] have been synthesized and characterized by elemental analysis,IR and 1H NMR spectroscopy and X-ray crystallography diffraction analyses. The molecular structure of(1) shows that Pt(II) ion has a square planar geometry with N(3) bonded heterocycle ligand, two cis chlorideanions and S-bonded dimethylsulfoxide. The antiproliferative activity of complexes (1) and (2) hasbeen tested in vitro against HepG2 human hepatoma cells and non-malignant human-derived hepaticcells (Chang). Complex (1), cis-[PtCl2(DMSO)HL] 2DMSO, was effective inducer of apoptotic death onHepG2 cells and its cytotoxic activity was higher than that exerted by cisplatin. Apoptosis effect wasassociated with externalization of plasma membrane phosphatidylserine.
Lingua originaleEnglish
pagine (da-a)112-118
Numero di pagine7
RivistaInorganica Chimica Acta
Volume418
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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