Synthesis of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one

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Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position.The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity againstthe HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6bshowed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines.
Lingua originaleEnglish
pagine (da-a)3374-3379
Numero di pagine6
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1600.1605???


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