Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d]pyrazine and Its Deaza Analogue

Risultato della ricerca: Articlepeer review

11 Citazioni (Scopus)

Abstract

Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d]pyrazine-6,13-dione and its deaza analogue pyrido[4'',3'':4',5']pyrrolo-[1',2':4,5]pyrazino[1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence.Symmetrical derivatives of the former ring system were obtained through selfcondensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ringsystem were tested by the National Cancer Institute (Bethesda, MD, USA) and four ofthem exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31(a renal cancer cell line).
Lingua originaleEnglish
pagine (da-a)13342-13357
Numero di pagine16
RivistaMolecules
Volume19
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Entra nei temi di ricerca di 'Synthesis of the New Ring System Bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d]pyrazine and Its Deaza Analogue'. Insieme formano una fingerprint unica.

Cita questo