Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

Paola Barraja; Patrizia Diana; Girolamo Cirrincione; Virginia Spano'; Anna Carbone

Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

Paola Barraja, Patrizia Diana, Girolamo Cirrincione, Virginia Spano', Anna Carbone

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

31 Citazioni (Scopus)

Abstract

A convenient synthesis of the pyrrolo[3,4-h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).

Lingua originale	English
pagine (da-a)	5389-5391
Numero di pagine	3
Rivista	Tetrahedron Letters
Volume	50
Stato di pubblicazione	Published - 2009

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline",

abstract = "A convenient synthesis of the pyrrolo[3,4-h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).",

keywords = "4-h ]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation, Pyrrolo[3, 4-h ]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation, Pyrrolo[3",

author = "Paola Barraja and Patrizia Diana and Girolamo Cirrincione and Virginia Spano' and Anna Carbone",

year = "2009",

language = "English",

volume = "50",

pages = "5389--5391",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

AU - Barraja, Paola

AU - Diana, Patrizia

AU - Cirrincione, Girolamo

AU - Spano', Virginia

AU - Carbone, Anna

PY - 2009

Y1 - 2009

N2 - A convenient synthesis of the pyrrolo[3,4-h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).

AB - A convenient synthesis of the pyrrolo[3,4-h ]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46–18.4 μM).

KW - 4-h ]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation

KW - Pyrrolo[3

KW - 4-h ]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation

KW - Pyrrolo[3

UR - http://hdl.handle.net/10447/43886

M3 - Article

VL - 50

SP - 5389

EP - 5391

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

ER -