Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin

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Abstract

A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.
Lingua originaleEnglish
pagine (da-a)4182-4184
Numero di pagine3
RivistaTetrahedron Letters
Volume50
Stato di pubblicazionePublished - 2009

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Oxazines
Phototoxic Dermatitis
Indoles
Derivatives
indole
angelicin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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title = "Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin",
abstract = "A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.",
keywords = "1,4-Oxazinoindoles; 1,4-Benzoxazines; Angelicin heteroanalogue; 4-Amino-5-hydroxy indoles",
author = "Girolamo Cirrincione and Patrizia Diana and Alessandra Montalbano and Annamaria Martorana and Anna Carbone",
year = "2009",
language = "English",
volume = "50",
pages = "4182--4184",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",

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TY - JOUR

T1 - Synthesis of the New Ring System 2-Oxo-[1,4]oxazino[3,2-e]indole, Heteroanalogue of Angelicin

AU - Cirrincione, Girolamo

AU - Diana, Patrizia

AU - Montalbano, Alessandra

AU - Martorana, Annamaria

AU - Carbone, Anna

PY - 2009

Y1 - 2009

N2 - A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.

AB - A series of 2-oxo-[1,4]oxazino[3,2-e ]indoles, heteroanalogues of Angelicin, have been synthesized by a multistep sequence consisting of the annelation of the oxazine ring on the indole moiety. The phototoxicity and the antiproliferative activity of the new derivatives were investigated.

KW - 1,4-Oxazinoindoles; 1,4-Benzoxazines; Angelicin heteroanalogue; 4-Amino-5-hydroxy indoles

UR - http://hdl.handle.net/10447/43884

M3 - Article

VL - 50

SP - 4182

EP - 4184

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

ER -