Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and6-imino-5-yl thiourea derivatives

Risultato della ricerca: Articlepeer review

Abstract

A series of substituted 1-(5-bromopyridin-2-yl)-3-[2-(isoindolo[2,1-a]quinoxalin-6-ylamino)ethyl]thiourea and 1-(5-bromopyridin-2-yl)-3-[2-(6-iminoisoindolo[2,1-a]quinoxalin-5(6H)-yl)ethyl]thiourea derivatives were prepared in good yields (63-85%) by reaction betweenthe corresponding amino compounds with 5-bromo-2-isothiocyanatopyridine. All thioureaderivatives, tested for inhibition of HIV-1 RT, showed no significant antiviral activity.
Lingua originaleEnglish
pagine (da-a)384-398
Numero di pagine15
RivistaArkivoc
Volumev
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1600.1605???

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