Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents

Vincenzo Cilibrasi, Helen L. Wiggins, Andrew D. Westwell, Matteo Morelli, Helen L. Wiggins, Francesca Solfa, Kwok Tsang, Vincenzo Cilibrasi, Arwyn T. Jones

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.
Lingua originaleEnglish
pagine (da-a)2583-2585
Numero di pagine3
RivistaTetrahedron Letters
Volume56
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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