Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Anna Carbone, Erik De Clercq, Maria Zappalà, Christophe Pannecouque, Jan Balzarini, Pietro Monforte, Anna Carbone, Alba Chimirri, Anna Maria Monforte, Angela Rao

Risultato della ricerca: Articlepeer review

91 Citazioni (Scopus)

Abstract

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30–50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
Lingua originaleEnglish
pagine (da-a)33-39
Numero di pagine7
RivistaIL FARMACO
Volume59
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3002???

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