Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Anna Carbone; Erik De Clercq; Maria Zappalà; Christophe Pannecouque; Jan Balzarini; Pietro Monforte; Anna Carbone; Alba Chimirri; Anna Maria Monforte; Angela Rao

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Anna Carbone, Erik De Clercq, Maria Zappalà, Christophe Pannecouque, Jan Balzarini, Pietro Monforte, Anna Carbone, Alba Chimirri, Anna Maria Monforte, Angela Rao

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

96 Citazioni (Scopus)

Abstract

Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30–50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

Lingua originale	English
pagine (da-a)	33-39
Numero di pagine	7
Rivista	IL FARMACO
Volume	59
Stato di pubblicazione	Published - 2004

All Science Journal Classification (ASJC) codes

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title = "Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents",

abstract = "Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30–50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).",

author = "Anna Carbone and {De Clercq}, Erik and Maria Zappal{\`a} and Christophe Pannecouque and Jan Balzarini and Pietro Monforte and Anna Carbone and Alba Chimirri and Monforte, {Anna Maria} and Angela Rao",

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T1 - Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

AU - Carbone, Anna

AU - De Clercq, Erik

AU - Zappalà, Maria

AU - Pannecouque, Christophe

AU - Balzarini, Jan

AU - Monforte, Pietro

AU - Carbone, Anna

AU - Chimirri, Alba

AU - Monforte, Anna Maria

AU - Rao, Angela

PY - 2004

Y1 - 2004

N2 - Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30–50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

AB - Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30–50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).

UR - http://hdl.handle.net/10447/12191

M3 - Article

SN - 0014-827X

VL - 59

SP - 33

EP - 39

JO - Farmaco

JF - Farmaco

ER -

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Abstract

All Science Journal Classification (ASJC) codes

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