Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Cristina Ciancimino; Anna Carbone; Girolamo Cirrincione; Barbara Parrino; Virginia Spano'; Alessandra Montalbano; Paola Barraja; Patrizia Diana

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Cristina Ciancimino, Anna Carbone, Girolamo Cirrincione, Barbara Parrino, Virginia Spano', Alessandra Montalbano, Paola Barraja, Patrizia Diana

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article

18 Citazioni (Scopus)

Abstract

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI<inf>50</inf> mean values at low micromolar level (3.72-5.13 μM).

Lingua originale	English
pagine (da-a)	7332-7338
Numero di pagine	7
Rivista	Tetrahedron
Volume	71
Stato di pubblicazione	Published - 2015

All Science Journal Classification (ASJC) codes

Organic Chemistry
Biochemistry
Drug Discovery

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Cita questo

Ciancimino, C., Carbone, A., Cirrincione, G., Parrino, B., Spano', V., Montalbano, A., Barraja, P., & Diana, P. (2015). Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest. Tetrahedron, 71, 7332-7338.

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title = "Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest",

abstract = "Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).",

author = "Cristina Ciancimino and Anna Carbone and Girolamo Cirrincione and Barbara Parrino and Virginia Spano' and Alessandra Montalbano and Paola Barraja and Patrizia Diana",

year = "2015",

language = "English",

volume = "71",

pages = "7332--7338",

journal = "Tetrahedron",

issn = "0040-4020",

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TY - JOUR

T1 - Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

AU - Ciancimino, Cristina

AU - Carbone, Anna

AU - Cirrincione, Girolamo

AU - Parrino, Barbara

AU - Spano', Virginia

AU - Montalbano, Alessandra

AU - Barraja, Paola

AU - Diana, Patrizia

PY - 2015

Y1 - 2015

N2 - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

AB - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

UR - http://hdl.handle.net/10447/147536

UR - http://www.journals.elsevier.com/tetrahedron/

M3 - Article

VL - 71

SP - 7332

EP - 7338

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

ER -