Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Barbara Parrino; Paola Barraja; Alessandra Montalbano; Girolamo Cirrincione; Cristina Ciancimino; Anna Carbone; Patrizia Diana; Virginia Spano'

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Barbara Parrino, Paola Barraja, Alessandra Montalbano, Girolamo Cirrincione, Cristina Ciancimino, Anna Carbone, Patrizia Diana, Virginia Spano'

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

28 Citazioni (Scopus)

Abstract

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

Lingua originale	English
pagine (da-a)	7332-7338
Numero di pagine	7
Rivista	Tetrahedron
Volume	71
Stato di pubblicazione	Published - 2015

All Science Journal Classification (ASJC) codes

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title = "Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest",

abstract = "Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).",

author = "Barbara Parrino and Paola Barraja and Alessandra Montalbano and Girolamo Cirrincione and Cristina Ciancimino and Anna Carbone and Patrizia Diana and Virginia Spano'",

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language = "English",

volume = "71",

pages = "7332--7338",

journal = "Tetrahedron",

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TY - JOUR

T1 - Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

AU - Parrino, Barbara

AU - Barraja, Paola

AU - Montalbano, Alessandra

AU - Cirrincione, Girolamo

AU - Ciancimino, Cristina

AU - Carbone, Anna

AU - Diana, Patrizia

AU - Spano', Virginia

PY - 2015

Y1 - 2015

N2 - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

AB - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

UR - http://hdl.handle.net/10447/147536

UR - http://www.journals.elsevier.com/tetrahedron/

M3 - Article

VL - 71

SP - 7332

EP - 7338

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

ER -

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Abstract

All Science Journal Classification (ASJC) codes

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