Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

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18 Citazioni (Scopus)

Abstract

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI<inf>50</inf> mean values at low micromolar level (3.72-5.13 μM).
Lingua originaleEnglish
pagine (da-a)7332-7338
Numero di pagine7
RivistaTetrahedron
Volume71
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Biochemistry
  • Drug Discovery

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