Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Risultato della ricerca: Article

16 Citazioni (Scopus)

Abstract

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI<inf>50</inf> mean values at low micromolar level (3.72-5.13 μM).
Lingua originaleEnglish
pagine (da-a)7332-7338
Numero di pagine7
RivistaTetrahedron
Volume71
Stato di pubblicazionePublished - 2015

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Isoindoles
Benzoxazines
Cyclization
Tumor Cell Line
Tumors
Cells
Derivatives
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest. /.

In: Tetrahedron, Vol. 71, 2015, pag. 7332-7338.

Risultato della ricerca: Article

(edd.) 2015, 'Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest', Tetrahedron, vol. 71, pagg. 7332-7338.
Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest. Tetrahedron. 2015;71:7332-7338.
/ Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest. In: Tetrahedron. 2015 ; Vol. 71. pagg. 7332-7338.
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abstract = "Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).",
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AU - Cirrincione, Girolamo

AU - Diana, Patrizia

AU - Montalbano, Alessandra

AU - Spano', Virginia

AU - Parrino, Barbara

AU - Carbone, Anna

AU - Ciancimino, Cristina

PY - 2015

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N2 - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

AB - Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).

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UR - http://www.journals.elsevier.com/tetrahedron/

M3 - Article

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JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

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