The reaction of various 1,2,4-oxadiazoles with an excessof hydrazine in DMF has been investigated. 3-Amino-1,2,4-triazoles are produced through a reductive ANRORCpathway consisting of the addition of hydrazine to the1,2,4-oxadiazole followed by ring-opening, ring-closure,and final reduction of the 3-hydroxylamino-1,2,4-triazoleintermediate. The general applicability of 1,2,4-oxadiazolesANRORC reactivity is demonstrated also in theabsence of C(5)-linked electron-withdrawing groups.
|Numero di pagine||4|
|Rivista||Journal of Organic Chemistry|
|Stato di pubblicazione||Published - 2010|
All Science Journal Classification (ASJC) codes
- Organic Chemistry