TY - JOUR
T1 - Synthesis of alkyl-5,8-dimethyl-6-phenyl-5,6-dihydropyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-ones of pharmaceutical interest
AU - Plescia, Fabiana
AU - Raimondi, Maria Valeria
AU - Cascioferro, Stella Maria
AU - Raffa, Demetrio
AU - Maggio, Benedetta
AU - Daidone, Giuseppe
PY - 2006
Y1 - 2006
N2 - The multistep synthesis of two pyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one derivatives, a new class of fused 1,2,3,5-tetrazepinones with potential antiproliferative activity, has been carried out. Owing to the instability of the above compounds, the last step of the synthesis was performed at -5/0 degrees C. The obtained tetrazepinones, when allowed to stand at r.t. for 24 h, afforded quantitatively 1-phenyl-3,6-dimethylpyrazolo [3,4-d][1,2,3] triazole.
AB - The multistep synthesis of two pyrazolo[3,4-f][1,2,3,5]tetrazepin-4(3H)-one derivatives, a new class of fused 1,2,3,5-tetrazepinones with potential antiproliferative activity, has been carried out. Owing to the instability of the above compounds, the last step of the synthesis was performed at -5/0 degrees C. The obtained tetrazepinones, when allowed to stand at r.t. for 24 h, afforded quantitatively 1-phenyl-3,6-dimethylpyrazolo [3,4-d][1,2,3] triazole.
UR - http://hdl.handle.net/10447/19902
UR - http://www.arkat-usa.org/get-file/22847/
M3 - Article
VL - XV
SP - 120
EP - 126
JO - Arkivoc
JF - Arkivoc
SN - 1551-7004
ER -