A novel base-induced rearrangement of isoxazoles into imidazole derivatives is reported. In theisoxazole series, this represents the first example of a three-atom side-chain rearrangementinvolving a CNC sequence. The reactions are carried out under nitrogen and produced2-aryl-4(5)-phenacyl-5(4)-phenyl-imidazoles in high yields. In the presence of oxygen, a cascaderearrangement-oxidation reaction sequence was observed and imidazole derivatives bearing an oxidizedside-chain were isolated.
|Numero di pagine||6|
|Rivista||ORGANIC & BIOMOLECULAR CHEMISTRY|
|Stato di pubblicazione||Published - 2011|
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