Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents

Paola Barraja, Patrizia Diana, Barbara Parrino, Daniele Giallombardo, Girolamo Cirrincione, Alessandra Montalbano, Anna Carbone, Virginia Spano', Virginia Spanò, Barbara Parrino, Daniele Giallombardo, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Risultato della ricerca: Article

31 Citazioni (Scopus)


A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with goodyields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-onesystem was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride.Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda andone of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generallyat low micromolar concentrations.
Lingua originaleEnglish
pagine (da-a)6474-6477
Numero di pagine4
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Barraja, P., Diana, P., Parrino, B., Giallombardo, D., Cirrincione, G., Montalbano, A., Carbone, A., Spano', V., Spanò, V., Parrino, B., Giallombardo, D., Carbone, A., Montalbano, A., Barraja, P., Cirrincione, G., & Diana, P. (2013). Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents. Tetrahedron, 69, 6474-6477.