Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents

Patrizia Diana, Alessandra Montalbano, Virginia Spano', Anna Carbone, Daniele Giallombardo, Paola Barraja, Barbara Parrino, Girolamo Cirrincione, Virginia Spanò, Barbara Parrino, Daniele Giallombardo, Anna Carbone, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana

Risultato della ricerca: Articlepeer review

33 Citazioni (Scopus)

Abstract

A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with goodyields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-onesystem was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride.Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda andone of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generallyat low micromolar concentrations.
Lingua originaleEnglish
pagine (da-a)6474-6477
Numero di pagine4
RivistaTetrahedron
Volume69
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3002???
  • ???subjectarea.asjc.1600.1605???

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