Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents

Girolamo Cirrincione, Paola Barraja, Patrizia Diana, Alessandra Montalbano, Virginia Spano', Barbara Parrino, Anna Carbone, Daniele Giallombardo, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Virginia Spanò, Barbara Parrino, Daniele Giallombardo, Anna Carbone

Risultato della ricerca: Article

31 Citazioni (Scopus)

Abstract

A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with good yields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-one system was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda and one of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generally at low micromolar concentrations.
Lingua originaleEnglish
pagine (da-a)6474-6477
Numero di pagine4
RivistaTetrahedron
Volume69
Stato di pubblicazionePublished - 2013

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Indazoles
Antineoplastic Agents
Oxazoles
Derivatives
Growth Inhibitors
Hydroxylamine
National Cancer Institute (U.S.)
Tumor Cell Line
Tumors
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cita questo

Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents. / Cirrincione, Girolamo; Barraja, Paola; Diana, Patrizia; Montalbano, Alessandra; Spano', Virginia; Parrino, Barbara; Carbone, Anna; Giallombardo, Daniele; Montalbano, Alessandra; Barraja, Paola; Cirrincione, Girolamo; Diana, Patrizia; Spanò, Virginia; Parrino, Barbara; Giallombardo, Daniele; Carbone, Anna.

In: Tetrahedron, Vol. 69, 2013, pag. 6474-6477.

Risultato della ricerca: Article

Cirrincione, G, Barraja, P, Diana, P, Montalbano, A, Spano', V, Parrino, B, Carbone, A, Giallombardo, D, Montalbano, A, Barraja, P, Cirrincione, G, Diana, P, Spanò, V, Parrino, B, Giallombardo, D & Carbone, A 2013, 'Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents', Tetrahedron, vol. 69, pagg. 6474-6477.
Cirrincione G, Barraja P, Diana P, Montalbano A, Spano' V, Parrino B e altri. Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents. Tetrahedron. 2013;69:6474-6477.
Cirrincione, Girolamo ; Barraja, Paola ; Diana, Patrizia ; Montalbano, Alessandra ; Spano', Virginia ; Parrino, Barbara ; Carbone, Anna ; Giallombardo, Daniele ; Montalbano, Alessandra ; Barraja, Paola ; Cirrincione, Girolamo ; Diana, Patrizia ; Spanò, Virginia ; Parrino, Barbara ; Giallombardo, Daniele ; Carbone, Anna. / Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents. In: Tetrahedron. 2013 ; Vol. 69. pagg. 6474-6477.
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AU - Cirrincione, Girolamo

AU - Barraja, Paola

AU - Diana, Patrizia

AU - Montalbano, Alessandra

AU - Spano', Virginia

AU - Parrino, Barbara

AU - Carbone, Anna

AU - Giallombardo, Daniele

AU - Montalbano, Alessandra

AU - Barraja, Paola

AU - Cirrincione, Girolamo

AU - Diana, Patrizia

AU - Spanò, Virginia

AU - Parrino, Barbara

AU - Giallombardo, Daniele

AU - Carbone, Anna

PY - 2013

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N2 - A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with good yields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-one system was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda and one of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generally at low micromolar concentrations.

AB - A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with good yields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-one system was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda and one of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generally at low micromolar concentrations.

KW - [1,2]Oxazolo[5,4-e]indazoles, Enaminoketones, Hydroxylamine hydrochloride, Antiproliferative activity

UR - http://hdl.handle.net/10447/80223

M3 - Article

VL - 69

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EP - 6477

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

ER -

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