TY - JOUR
T1 - Synthesis of [1,2]oxazolo[5,4-e]indazoles as antitumour agents
AU - Diana, Patrizia
AU - Montalbano, Alessandra
AU - Spano', Virginia
AU - Carbone, Anna
AU - Giallombardo, Daniele
AU - Barraja, Paola
AU - Parrino, Barbara
AU - Cirrincione, Girolamo
AU - Spanò, Virginia
AU - Parrino, Barbara
AU - Giallombardo, Daniele
AU - Carbone, Anna
AU - Montalbano, Alessandra
AU - Barraja, Paola
AU - Cirrincione, Girolamo
AU - Diana, Patrizia
PY - 2013
Y1 - 2013
N2 - A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with goodyields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-onesystem was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride.Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda andone of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generallyat low micromolar concentrations.
AB - A series of 40 derivatives of the [1,2]oxazolo[5,4-e]indazoles ring system have been prepared with goodyields using a versatile and convenient route. Annelation of the [1,2]oxazole ring on the indazole-4-onesystem was achieved by reaction of the corresponding enaminoketones with hydroxylamine hydrochloride.Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda andone of them (13t) showed growth-inhibitor activity against all the 54 human tumour cell lines generallyat low micromolar concentrations.
KW - 2]Oxazolo[5
KW - 4-e]indazoles
KW - Antiproliferative activity
KW - Enaminoketones
KW - Hydroxylamine hydrochloride
KW - [1
KW - 2]Oxazolo[5
KW - 4-e]indazoles
KW - Antiproliferative activity
KW - Enaminoketones
KW - Hydroxylamine hydrochloride
KW - [1
UR - http://hdl.handle.net/10447/80223
M3 - Article
VL - 69
SP - 6474
EP - 6477
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
ER -