TY - JOUR
T1 - Synthesis, Characterization and in vitro antimicrobial activity of dialkyltin(IV)bis(fusidate) complexes.
AU - Cataldo, Salvatore
AU - Scopelliti, Michelangelo
AU - Pellerito, Lorenzo
AU - Pellerito, Claudia
AU - Prinzivalli, Cristina
AU - Schillaci, Domenico
AU - Fiore, Tiziana
AU - Casella, Girolamo
AU - Abbate, Michele
PY - 2008
Y1 - 2008
N2 - The complexation of one steroid antibiotic of the fusidane family, sodium fusidate [sodium 2-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12, 13,15,16-dodeca hydro-1H-cyclopenta[a]phenanthren-7-ylidene)-6-methyl-hept-5-enoate = (Nafus)], by dialkyltin(IV) has been studied by conventional technique as FT-IR, Mössbauer and NMR spectroscopies. Analytical data supported the general formula Alk2Sn(IV)fus2 (Alk = Me, Bu). Infrared spectral data of the complexes imply the presence of both uni- and bidentate, ester-type and bridging carboxylate group, respectively. On the basis of FT-IR and 119Sn Mössbauer spectroscopy, in both Me2Sn(IV)fus2 and Bu2Sn(IV)fus2, trigonal bipyramidal configurations are proposed. NMR spectra, of both ligand and of the complexes were carried in DMSO-d6 solution, in which dialkyltin(IV)bis(fusidate) maintained their solid-state configuration. In vitro antimicrobial tests were performed on complexes, and good anti-staphylococcal activity was observed.
AB - The complexation of one steroid antibiotic of the fusidane family, sodium fusidate [sodium 2-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12, 13,15,16-dodeca hydro-1H-cyclopenta[a]phenanthren-7-ylidene)-6-methyl-hept-5-enoate = (Nafus)], by dialkyltin(IV) has been studied by conventional technique as FT-IR, Mössbauer and NMR spectroscopies. Analytical data supported the general formula Alk2Sn(IV)fus2 (Alk = Me, Bu). Infrared spectral data of the complexes imply the presence of both uni- and bidentate, ester-type and bridging carboxylate group, respectively. On the basis of FT-IR and 119Sn Mössbauer spectroscopy, in both Me2Sn(IV)fus2 and Bu2Sn(IV)fus2, trigonal bipyramidal configurations are proposed. NMR spectra, of both ligand and of the complexes were carried in DMSO-d6 solution, in which dialkyltin(IV)bis(fusidate) maintained their solid-state configuration. In vitro antimicrobial tests were performed on complexes, and good anti-staphylococcal activity was observed.
KW - Dialkyltin(IV)
KW - FT-IR
KW - Mössbauer
KW - NMR
KW - antimicrobial tests
KW - Dialkyltin(IV)
KW - FT-IR
KW - Mössbauer
KW - NMR
KW - antimicrobial tests
UR - http://hdl.handle.net/10447/35138
M3 - Article
VL - SERIE QUINTA, VOL. XXIV (TOMO I: Scienze)
SP - 75
EP - 88
JO - ATTI DELLA ACCADEMIA DI SCIENZE, LETTERE E ARTI DI PALERMO, PARTE PRIMA: SCIENZE
JF - ATTI DELLA ACCADEMIA DI SCIENZE, LETTERE E ARTI DI PALERMO, PARTE PRIMA: SCIENZE
SN - 0365-0448
ER -