Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpirrole and X-ray structure of bis[2-benzoylpirrolato(N,O)]copper (II).

Simona Rubino, Giancarlo Stocco, Salvatore Petruso, Giuseppe Bruno, E. Del Giudice, Motta, Passerotto, Pierattelli, Luca Steardo

Risultato della ricerca: Article

8 Citazioni (Scopus)

Abstract

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole (2-BZPH) were synthesized and characterized with IR, 1H, and 12C NMR spectroscopies and coordination geometry with ligands arranged in transoid fashion. The crystal structure of [CuII (2-BZPH)2] was determined by X-ray diffraction. Death of complex treated Jurkat cells was measured by flow cytometry. The bis-chelate complexes [CuII (2-BZPH)2] and [PtII (2-BZPH)2] adopt square-planar coordination geometry with ligands, arranged in transoid fashion. Concentrations of 1-10µM Platinum(II) complexes reduced cell survival from 100% to 20%, in contrast to the copper(II) complex which caused no cell death at a concentration of 10 µM. While the PtII complexes may have damaged DNA to induce cell death, treatment with the CuII complex did not induce Jurkat cell death.
Lingua originaleEnglish
pagine (da-a)2071-2079
Numero di pagine9
RivistaJournal of Inorganic Biochemistry
Volume98
Stato di pubblicazionePublished - 2004

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry

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