Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality

Giuseppe Daidone, Benedetta Maggio, Demetrio Raffa, Marianna Lauricella, Fabiana Plescia, Antonella D'Anneo, Stella Maria Cascioferro, Maria Valeria Raimondi, Maria Grazia Cusimano, Gabriella Cancemi, Stella Cascioferro, Demetrio Raffa, Giuseppe Daidone, Maria Valeria Raimondi, Benedetta Maggio, Ruoli Bai, Maria Grazia Cusimano, Ernest Hamel, Gabriella Cancemi, Fabiana Plescia

Risultato della ricerca: Article

9 Citazioni (Scopus)

Abstract

Several new 2-(2-phenoxyacetamido)benzamides 17a-v were synthesized by stirring in pyridine the acid chlorides 16a-e and the appropriate5-R-4-R1-2-aminobenzamide 15a-e and initially evaluated in vitro for antiproliferative activity against the K562 (human chronic myelogenous leukemia) cell line. Some of synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). The most active compounds caused an arrest of K562 cells in the G0-G1 phase of cell cycle and induction of apoptosis, which was mediated by caspase activation.
Lingua originaleEnglish
pagine (da-a)6305-6316
Numero di pagine12
RivistaBIOORGANIC & MEDICINAL CHEMISTRY
Volume23
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Clinical Biochemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Molecular Biology
  • Molecular Medicine

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